Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCN4 | Q9Y3Q4 | 7/20 | 0.54 |
| ▸ | BRD4 | O60885 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9739668 | 1.00 | HCN4 (0.54) | HCN4BRD4GAASMPD1MEN1 | |
| Hydrochloric Acid SCHEMBL10766227 | 0.99 | HCN4 (0.53) | HCN4BRD4GAASMPD1MEN1 | |
| SCHEMBL9739670 | 0.95 | HCN4 (0.55) | HCN4BRD4MAPTALDH1A1HTT | |
| Hydrochloric Acid SCHEMBL9738862 | 0.90 | HCN4 (0.44) | HCN4GAAMEN1KMT2AMAPT | |
| SCHEMBL9738933 | 0.84 | BCHE (0.45) | BRD4SIGMAR1 | |
| SCHEMBL9739274 | 0.82 | CHRNB4 (0.44) | HCN4BRD4 | |
| SCHEMBL9738909 | 0.81 | BCHE (0.44) | BRD4SIGMAR1 | |
| SCHEMBL9213553 | 0.81 | BRD4 (0.40) | HCN4BRD4MEN1KMT2A | |
| SCHEMBL9212352 | 0.81 | ACHE (0.43) | HCN4BRD4MEN1KMT2AALDH1A1 | |
| Cilobradine SCHEMBL30169956 | 0.81 | HCN4 (0.57) | HCN4GAASMPD1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5175157-A | Cardiovascular disorders | BOEHRINGER INGELHEIM GMBH (DE) | 1992-12-29 | — | — | US | disclosed |