Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX12 | P18054 | 2/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | HSPA5 | P11021 | 1/20 | 0.36 |
| ▸ | HSPA2 | P54652 | 1/20 | 0.36 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.35 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.34 |
| ▸ | CIT | O14578 | 2/20 | 0.34 |
| ▸ | SCN9A | Q15858 | 3/20 | 0.33 |
| ▸ | CNR2 | P34972 | 2/20 | 0.33 |
| ▸ | FNTA | P49354 | 1/20 | 0.33 |
| ▸ | FNTB | P49356 | 1/20 | 0.33 |
| ▸ | PGGT1B | P53609 | 1/20 | 0.33 |
| ▸ | FFAR2 | O15552 | 1/20 | 0.33 |
| ▸ | CNR1 | P21554 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9739682 | 1.00 | ALOX12 (0.36) | ALOX12ALOX15HSPA5HSPA2ADAM17 | |
| SCHEMBL7279293 | 0.88 | ALOX12 (0.40) | ALOX12ALOX15HSPA5HSPA2ADAM17 | |
| SCHEMBL7279299 | 0.88 | ALOX12 (0.40) | ALOX12ALOX15HSPA5HSPA2ADAM17 | |
| Hydrochloric Acid SCHEMBL9741701 | 0.87 | ALOX12 (0.40) | ALOX12ALOX15HSPA5HSPA2ADAM17 | |
| Hydrochloric Acid SCHEMBL9741705 | 0.87 | ALOX12 (0.40) | ALOX12ALOX15HSPA5HSPA2ADAM17 | |
| SCHEMBL9741250 | 0.81 | BACE1 (0.45) | — | |
| SCHEMBL9741242 | 0.81 | BACE1 (0.45) | — | |
| SCHEMBL9740697 | 0.79 | REN (0.41) | CNR2CNR1 | |
| SCHEMBL7424256 | 0.79 | REN (0.41) | CNR2CNR1 | |
| SCHEMBL9740699 | 0.79 | REN (0.41) | CNR2CNR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5104869-A | Renin inhibitors | AMERICAN CYANAMID COMPANY (US) | 1992-04-14 | — | — | US | disclosed |
| EP-0427939-A2 | Renin inhibitors | AMERICAN CYANAMID COMPANY (US) | 1991-05-22 | — | — | EP | disclosed |