Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | ELANE | P08246 | 4/20 | 0.47 |
| ▸ | PTGDR | Q13258 | 1/20 | 0.45 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.45 |
| ▸ | EGFR | P00533 | 1/20 | 0.45 |
| ▸ | PTGER1 | P34995 | 2/20 | 0.44 |
| ▸ | PTGER4 | P35408 | 2/20 | 0.44 |
| ▸ | PTGER3 | P43115 | 2/20 | 0.44 |
| ▸ | PTGER2 | P43116 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.43 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9417793 | 0.88 | KDM4E (0.43) | NPC1HPGDRAB9ASMN1; SMN2ELANE | |
| SCHEMBL9417931 | 0.87 | MRGPRX4 (0.47) | ELANEPTGER1PTGER4PTGER3PTGER2 | |
| SCHEMBL9528336 | 0.86 | MRGPRX4 (0.53) | NPC1HPGDRAB9ASMN1; SMN2ELANE | |
| SCHEMBL9739697 | 0.81 | NPC1 (0.56) | NPC1HPGDRAB9ASMN1; SMN2EGFR | |
| SCHEMBL9417760 | 0.81 | KDM4E (0.50) | SMN1; SMN2ELANEPTGDRPTGDR2KDM4E | |
| SCHEMBL9734673 | 0.81 | PTGDR (0.45) | SMN1; SMN2ELANEPTGDRPTGDR2KDM4E | |
| SCHEMBL9417839 | 0.80 | KDM4E (0.46) | SMN1; SMN2ELANEPTGDRPTGDR2KDM4E | |
| SCHEMBL9417943 | 0.80 | PTGDR (0.47) | SMN1; SMN2ELANEPTGDRPTGDR2KDM4E | |
| SCHEMBL27639554 | 0.79 | PPARG (0.45) | NPC1HPGDRAB9ASMN1; SMN2EGFR | |
| SCHEMBL9733519 | 0.79 | PTPN1 (0.56) | ELANEKDM4EMEN1KMT2APTPN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5294613-A | Benzene derivatives of p-substituted ether and acid or ester | ELI LILLY AND COMPANY (US) | 1994-03-15 | — | — | US | disclosed |
| US-5098613-A | Aromatic ethers for treatment of mammals | ELI LILLY AND COMPANY (US) | 1992-03-24 | — | — | US | disclosed |
| US-4945099-A | LEUKOTRIENE ANTAGONIST | ELI LILLY AND COMPANY (US) | 1990-07-31 | — | — | US | disclosed |
| EP-0276065-B1 | ANTI-INFLAMMATORY AGENTS | ELI LILLY AND COMPANY (US) | 1990-06-06 | — | — | EP | disclosed |