Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.48 |
| ▸ | HTR2A | P28223 | 2/20 | 0.48 |
| ▸ | DRD2 | P14416 | 1/20 | 0.48 |
| ▸ | HTR2C | P28335 | 1/20 | 0.48 |
| ▸ | HTR2B | P41595 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | GRIN1 | Q05586 | 3/20 | 0.45 |
| ▸ | GRIN2B | Q13224 | 3/20 | 0.45 |
| ▸ | LTA4H | P09960 | 1/20 | 0.44 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.44 |
| ▸ | HTR1A | P08908 | 4/20 | 0.44 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9740561 | 0.89 | CHRNB2 (0.49) | SIGMAR1MEN1KMT2ALTA4HEPHX2 | |
| SCHEMBL9740036 | 0.89 | MAPT (0.49) | MEN1KMT2AHTR1ASLC6A4 | |
| Hydrochloric Acid SCHEMBL9739064 | 0.88 | CHRNB2 (0.48) | MEN1KMT2A | |
| SCHEMBL9746442 | 0.86 | CHRNB2 (0.46) | SIGMAR1 | |
| SCHEMBL9739498 | 0.86 | ABCB1 (0.51) | MEN1KMT2A | |
| SCHEMBL9739855 | 0.86 | CHRNB2 (0.46) | MEN1KMT2ALTA4HEPHX2HTR1A | |
| SCHEMBL9740763 | 0.86 | MEN1 (0.53) | SIGMAR1MEN1KMT2A | |
| Hydrochloric Acid SCHEMBL9739563 | 0.86 | GAA (0.51) | MEN1KMT2A | |
| SCHEMBL9739940 | 0.86 | CCR2 (0.47) | LTA4HEPHX2KCNH2 | |
| SCHEMBL9739779 | 0.86 | CCR2 (0.41) | MEN1KMT2ALTA4HEPHX2KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5175157-A | Cardiovascular disorders | BOEHRINGER INGELHEIM GMBH (DE) | 1992-12-29 | — | — | US | disclosed |
| EP-0224794-B1 | CYCLIC AMINE DERIVATIVES, MEDICINES CONTAINING THESE COMPOUNDS AND PROCESS FOR THEIR PREPARATION | Dr. Karl Thomae GmbH (DE) | 1990-09-12 | — | — | EP | disclosed |
| EP-0224794-A2 | Cyclic amine derivatives, medicines containing these compounds and process for their preparation | Dr. Karl Thomae GmbH (DE) | 1987-06-10 | — | — | EP | disclosed |