SCHEMBL9740002

SCHEMBL9740002

Cc1nc2ccccn2c(=O)c1CCN1CC[C@@H](Nc2nc3ccccc3n2Cc2ccc(F)cc2)[C@@H](C)C1

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 2/20 0.52
CYP3A4 P08684 2/20 0.52
HTR1A P08908 2/20 0.52
CYP2D6 P10635 2/20 0.52
MAPT P10636 2/20 0.52
HTR2C P28335 2/20 0.52
KMT2A Q03164 2/20 0.52
SMN1; SMN2 Q16637 2/20 0.52
EED O75530 2/20 0.52
KDM4E B2RXH2 1/20 0.52
PKM P14618 1/20 0.52
HPGD P15428 1/20 0.52
TSHR P16473 1/20 0.52
THPO P40225 1/20 0.52
PMP22 Q01453 1/20 0.52
SSTR5 P35346 8/20 0.51
KCNH2 Q12809 8/20 0.49
NR4A2 P43354 2/20 0.49
HRH1 P35367 2/20 0.49
HRH4 Q9H3N8 2/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9740005 1.00 MEN1 (0.52) MEN1CYP3A4HTR1ACYP2D6MAPT
SCHEMBL9740008 1.00 MEN1 (0.52) MEN1CYP3A4HTR1ACYP2D6MAPT
SCHEMBL9536711 0.81 CYP2D6 (0.59) MEN1CYP3A4HTR1ACYP2D6MAPT
SCHEMBL9698401 0.80 SSTR5 (0.60) MEN1CYP3A4HTR1ACYP2D6MAPT
Hydrochloric Acid SCHEMBL9740582 0.80 CYP2D6 (0.56) MEN1CYP3A4HTR1ACYP2D6MAPT
Hydrochloric Acid SCHEMBL9536691 0.79 CYP2D6 (0.56) MEN1CYP3A4HTR1ACYP2D6MAPT
Hydrochloric Acid SCHEMBL9740587 0.79 CYP2D6 (0.56) MEN1CYP3A4HTR1ACYP2D6MAPT
Hydrochloric Acid SCHEMBL9800689 0.79 HTR1A (0.54) MEN1CYP3A4HTR1ACYP2D6MAPT
SCHEMBL9630594 0.78 ADRA2A (0.46) MEN1CYP3A4HTR1ACYP2D6MAPT
SCHEMBL9689852 0.77 HTR1A (0.46) MEN1CYP3A4HTR1ACYP2D6MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5126339-A Antihistamine, antiserotonine JANSSEN PHARMACEUTICA N.V. (BE) 1992-06-30 US disclosed
US-5025014-A Antiallergens JANSSEN PHARMACEUTICA N.V. (BE) 1991-06-18 US disclosed
US-4888426-A CHEMICAL INTERMEDIATES JANSSEN PHARMACEUTICA N.V. (BE) 1989-12-19 US disclosed