Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 1/20 | 0.45 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.44 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | CTRB1 | P17538 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 3/20 | 0.41 |
| ▸ | F2 | P00734 | 2/20 | 0.41 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.40 |
| ▸ | FASN | P49327 | 1/20 | 0.40 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL638641 | 1.00 | MAOB (0.45) | MAOBDDB1CRBNKMT2AALDH1A1 | |
| SCHEMBL9218388 | 0.82 | L3MBTL1 (0.44) | KMT2AALDH1A1RAB9AMEN1USP2 | |
| SCHEMBL31121820 | 0.82 | TSHR (0.35) | MAOBALDH1A1CTRB1TSHRL3MBTL1 | |
| SCHEMBL11754574 | 0.82 | MAOB (0.43) | MAOBDDB1CRBNKMT2AALDH1A1 | |
| SCHEMBL7610527 | 0.82 | ALDH1A1 (0.41) | DDB1CRBNKMT2AALDH1A1NPC1 | |
| SCHEMBL25252980 | 0.82 | MAOB (0.46) | MAOBKMT2AALDH1A1MEN1TSHR | |
| SCHEMBL60686 | 0.82 | FASN (0.45) | MAPTFASN | |
| SCHEMBL7434587 | 0.81 | MAOB (0.47) | MAOBDDB1CRBNKMT2AALDH1A1 | |
| SCHEMBL7431763 | 0.81 | MAOB (0.47) | MAOBDDB1CRBNKMT2AALDH1A1 | |
| SCHEMBL7431760 | 0.81 | MAOB (0.47) | MAOBDDB1CRBNKMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5104869-A | Renin inhibitors | AMERICAN CYANAMID COMPANY (US) | 1992-04-14 | — | — | US | disclosed |
| EP-0427939-A2 | Renin inhibitors | AMERICAN CYANAMID COMPANY (US) | 1991-05-22 | — | — | EP | disclosed |