Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 10/20 | 0.78 |
| ▸ | HTR2B | P41595 | 4/20 | 0.55 |
| ▸ | HTR2C | P28335 | 3/20 | 0.55 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | CALM1 | P0DP23 | 2/20 | 0.42 |
| ▸ | IGF1R | P08069 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9740770 | 0.88 | ALOX5 (1.00) | ALOX5HTR2BHTR2CALOX15RAB9A | |
| SCHEMBL9739730 | 0.80 | ALOX5 (0.52) | ALOX5HTR2BHTR2CRAB9AKDM4E | |
| SCHEMBL9739471 | 0.78 | ALOX5 (0.82) | ALOX5ALOX15CALM1 | |
| SCHEMBL9740821 | 0.77 | ALOX5 (0.48) | ALOX5HTR2BHTR2CALOX15ALDH1A1 | |
| SCHEMBL9741128 | 0.75 | ALOX5 (0.60) | ALOX5ALOX15ALDH1A1CALM1 | |
| SCHEMBL29256757 | 0.73 | CALM1 (0.55) | ALOX5HTR2BHTR2CALOX15RAB9A | |
| SCHEMBL10744144 | 0.73 | ALOX5 (0.57) | ALOX5HTR2BHTR2CRAB9ANPC1 | |
| SCHEMBL9740454 | 0.73 | ALOX5 (0.57) | ALOX5HTR2BHTR2CRAB9ANPC1 | |
| SCHEMBL10739689 | 0.71 | MAPT (0.50) | ALOX5HTR2BHTR2CALOX15RAB9A | |
| SCHEMBL9739868 | 0.70 | ALOX5 (0.84) | ALOX5ALOX15ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5087638-A | Inhibitors of mammalian leukotriene biosynthesis | MERCK FROSST CANADA, INC. (CA) | 1992-02-11 | — | — | US | disclosed |
| EP-0338782-A1 | Benzofuran derivatives | MERCK FROSST CANADA INC. (CA) | 1989-10-25 | — | — | EP | disclosed |
| US-4863958-A | TREATING ALLERGIC CONDITIONS, ASTHMA, CARDIOVASCULAR DISORDERS, AND INFLAMMATION | MERCK FROSST CANADA, INC. (CA) | 1989-09-05 | — | — | US | disclosed |
| EP-0165810-B1 | BENZOFURAN AND BENZOTHIOPHENE DERIVATIVES, THEIR USE IN INHIBITING MAMMALIAN LEUKOTRIENE BIOSYNTHESIS, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THESE DERIVATIVES | MERCK FROSST CANADA INC. (CA) | 1989-08-23 | — | — | EP | disclosed |
| EP-0165810-A2 | Benzofuran and benzothiophene derivatives, their use in inhibiting mammalian leukotriene biosynthesis, and pharmaceutical compositions containing these derivatives | MERCK FROSST CANADA INC. (CA) | 1985-12-27 | — | — | EP | disclosed |