Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 14/20 | 1.00 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.52 |
| ▸ | HTR2C | P28335 | 2/20 | 0.50 |
| ▸ | HTR2B | P41595 | 2/20 | 0.50 |
| ▸ | VKORC1 | Q9BQB6 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | LTA4H | P09960 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9740305 | 0.88 | ALOX5 (0.78) | ALOX5ALOX15HTR2CHTR2BNPC1 | |
| SCHEMBL9739633 | 0.78 | ALOX5 (0.72) | ALOX5ALOX15 | |
| SCHEMBL9739804 | 0.77 | ALOX5 (1.00) | ALOX5ALOX15 | |
| SCHEMBL9740040 | 0.76 | ALOX5 (1.00) | ALOX5ALOX15 | |
| SCHEMBL10515100 | 0.76 | ALOX5 (0.61) | ALOX5ALOX15 | |
| SCHEMBL10513840 | 0.75 | ALOX5 (0.71) | ALOX5ALOX15 | |
| SCHEMBL9739958 | 0.75 | ALOX5 (0.71) | ALOX5ALOX15 | |
| SCHEMBL9740774 | 0.75 | ALOX5 (0.74) | ALOX5ALOX15VKORC1 | |
| Hydrochloric Acid SCHEMBL9740357 | 0.75 | ALOX5 (0.71) | ALOX5ALOX15 | |
| SCHEMBL9739761 | 0.74 | ALOX5 (0.59) | ALOX5ALOX15NPC1MAPTRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-1316371-A | — | — | None | — | — | JP | disclosed |
| US-5087638-A | Inhibitors of mammalian leukotriene biosynthesis | MERCK FROSST CANADA, INC. (CA) | 1992-02-11 | — | — | US | disclosed |
| JP-H01316371-A | BENZOFURAN DERIVATIVE | MERCK FROSST CANADA INC | 1989-12-21 | — | — | JP | disclosed |
| EP-0338782-A1 | Benzofuran derivatives | MERCK FROSST CANADA INC. (CA) | 1989-10-25 | — | — | EP | disclosed |
| US-4863958-A | TREATING ALLERGIC CONDITIONS, ASTHMA, CARDIOVASCULAR DISORDERS, AND INFLAMMATION | MERCK FROSST CANADA, INC. (CA) | 1989-09-05 | — | — | US | disclosed |
| EP-0165810-B1 | BENZOFURAN AND BENZOTHIOPHENE DERIVATIVES, THEIR USE IN INHIBITING MAMMALIAN LEUKOTRIENE BIOSYNTHESIS, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THESE DERIVATIVES | MERCK FROSST CANADA INC. (CA) | 1989-08-23 | — | — | EP | disclosed |
| EP-0165810-A2 | Benzofuran and benzothiophene derivatives, their use in inhibiting mammalian leukotriene biosynthesis, and pharmaceutical compositions containing these derivatives | MERCK FROSST CANADA INC. (CA) | 1985-12-27 | — | — | EP | disclosed |