Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSS | P25774 | 1/20 | 0.51 |
| ▸ | CTSK | P43235 | 1/20 | 0.51 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.43 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.42 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.42 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.42 |
| ▸ | NR1D1 | P20393 | 1/20 | 0.42 |
| ▸ | MME | P08473 | 2/20 | 0.42 |
| ▸ | ACE | P12821 | 2/20 | 0.42 |
| ▸ | CPA1 | P15085 | 1/20 | 0.42 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10477661 | 0.85 | CTNNB1 (0.50) | CTNNB1TDP1L3MBTL1HRH4SLC1A3 | |
| SCHEMBL10477694 | 0.83 | ALDH1A1 (0.48) | CTNNB1TDP1L3MBTL1HRH4SLC1A3 | |
| SCHEMBL9554930 | 0.83 | MME (0.48) | CTNNB1TDP1L3MBTL1HRH4SLC1A3 | |
| SCHEMBL9554924 | 0.83 | MME (0.48) | CTNNB1TDP1L3MBTL1HRH4SLC1A3 | |
| SCHEMBL7297927 | 0.83 | CTNNB1 (0.50) | CTSSCTSKCTNNB1TDP1L3MBTL1 | |
| SCHEMBL10389860 | 0.83 | CTNNB1 (0.50) | CTSSCTSKCTNNB1TDP1L3MBTL1 | |
| SCHEMBL1916013 | 0.83 | PPARG (0.46) | CPA1ALDH1A1 | |
| SCHEMBL9665093 | 0.83 | CTNNB1 (0.50) | CTSSCTSKCTNNB1TDP1L3MBTL1 | |
| SCHEMBL1916009 | 0.83 | PPARG (0.46) | CPA1ALDH1A1 | |
| SCHEMBL30192155 | 0.82 | CTSS (0.49) | CTSSCTSKCPA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5104869-A | Renin inhibitors | AMERICAN CYANAMID COMPANY (US) | 1992-04-14 | — | — | US | disclosed |
| EP-0427939-A2 | Renin inhibitors | AMERICAN CYANAMID COMPANY (US) | 1991-05-22 | — | — | EP | disclosed |