Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 16/20 | 0.73 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.50 |
| ▸ | CNR2 | P34972 | 1/20 | 0.40 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | XBP1 | P17861 | 1/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.38 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.37 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9742547 | 0.89 | ALOX5 (0.77) | ALOX5ALOX15 | |
| SCHEMBL9740795 | 0.86 | ALOX5 (0.73) | ALOX5ALOX15CNR2GPR55MAPT | |
| SCHEMBL9740040 | 0.85 | ALOX5 (1.00) | ALOX5ALOX15 | |
| SCHEMBL9740691 | 0.84 | ALOX5 (0.70) | ALOX5ALOX15LMNA | |
| SCHEMBL9740856 | 0.83 | ALOX5 (0.52) | ALOX5ALOX15CNR2GPR55LMNA | |
| SCHEMBL9741232 | 0.77 | ALOX5 (0.68) | ALOX5ALOX15 | |
| SCHEMBL9739471 | 0.74 | ALOX5 (0.82) | ALOX5ALOX15 | |
| SCHEMBL9740447 | 0.72 | ALOX5 (0.54) | ALOX5ALOX15 | |
| SCHEMBL9739462 | 0.72 | ALOX5 (1.00) | ALOX5ALOX15 | |
| SCHEMBL9740774 | 0.70 | ALOX5 (0.74) | ALOX5ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5087638-A | Inhibitors of mammalian leukotriene biosynthesis | MERCK FROSST CANADA, INC. (CA) | 1992-02-11 | — | — | US | disclosed |
| EP-0338782-A1 | Benzofuran derivatives | MERCK FROSST CANADA INC. (CA) | 1989-10-25 | — | — | EP | disclosed |
| US-4863958-A | TREATING ALLERGIC CONDITIONS, ASTHMA, CARDIOVASCULAR DISORDERS, AND INFLAMMATION | MERCK FROSST CANADA, INC. (CA) | 1989-09-05 | — | — | US | disclosed |
| EP-0165810-B1 | BENZOFURAN AND BENZOTHIOPHENE DERIVATIVES, THEIR USE IN INHIBITING MAMMALIAN LEUKOTRIENE BIOSYNTHESIS, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THESE DERIVATIVES | MERCK FROSST CANADA INC. (CA) | 1989-08-23 | — | — | EP | disclosed |