Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 13/20 | 0.54 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.43 |
| ▸ | HSD17B3 | P37058 | 1/20 | 0.39 |
| ▸ | ACP1 | P24666 | 1/20 | 0.37 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.35 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9740856 | 0.90 | ALOX5 (0.52) | ALOX5ALOX15PTPN1 | |
| SCHEMBL9739633 | 0.87 | ALOX5 (0.72) | ALOX5ALOX15MTNR1AMTNR1B | |
| SCHEMBL9742547 | 0.82 | ALOX5 (0.77) | ALOX5ALOX15PTPN1 | |
| SCHEMBL9740412 | 0.72 | ALOX5 (0.73) | ALOX5ALOX15 | |
| SCHEMBL9740795 | 0.71 | ALOX5 (0.73) | ALOX5ALOX15PTPN1MTNR1AMTNR1B | |
| SCHEMBL9739648 | 0.71 | ALOX5 (0.87) | ALOX5ALOX15HSD17B3 | |
| SCHEMBL9740040 | 0.70 | ALOX5 (1.00) | ALOX5ALOX15MTNR1AMTNR1B | |
| SCHEMBL9739329 | 0.70 | ALOX5 (0.55) | ALOX5ALOX15PTPN1MTNR1AMTNR1B | |
| SCHEMBL9740431 | 0.69 | ALOX5 (0.61) | ALOX5ALOX15MTNR1AMTNR1B | |
| SCHEMBL9740691 | 0.69 | ALOX5 (0.70) | ALOX5ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5087638-A | Inhibitors of mammalian leukotriene biosynthesis | MERCK FROSST CANADA, INC. (CA) | 1992-02-11 | — | — | US | disclosed |
| EP-0338782-A1 | Benzofuran derivatives | MERCK FROSST CANADA INC. (CA) | 1989-10-25 | — | — | EP | disclosed |
| US-4863958-A | TREATING ALLERGIC CONDITIONS, ASTHMA, CARDIOVASCULAR DISORDERS, AND INFLAMMATION | MERCK FROSST CANADA, INC. (CA) | 1989-09-05 | — | — | US | disclosed |
| EP-0165810-B1 | BENZOFURAN AND BENZOTHIOPHENE DERIVATIVES, THEIR USE IN INHIBITING MAMMALIAN LEUKOTRIENE BIOSYNTHESIS, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THESE DERIVATIVES | MERCK FROSST CANADA INC. (CA) | 1989-08-23 | — | — | EP | disclosed |
| EP-0165810-A2 | Benzofuran and benzothiophene derivatives, their use in inhibiting mammalian leukotriene biosynthesis, and pharmaceutical compositions containing these derivatives | MERCK FROSST CANADA INC. (CA) | 1985-12-27 | — | — | EP | disclosed |