Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCB1 | P08183 | 1/20 | 0.43 |
| ▸ | EBP | Q15125 | 2/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.40 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | HCN4 | Q9Y3Q4 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.39 |
| ▸ | HTR1A | P08908 | 1/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9739280 | 0.78 | HCN4 (0.59) | ABCB1MAPTHCN4CYP3A4ALOX15 | |
| SCHEMBL9206607 | 0.74 | ADRA1B (0.49) | ABCB1MAPTHCN4CYP3A4ALOX15 | |
| Hydrochloric Acid SCHEMBL9213924 | 0.74 | ADRA1B (0.49) | ABCB1MAPTHCN4CYP3A4ALOX15 | |
| Cilobradine SCHEMBL628133 | 0.73 | HCN4 (0.57) | SIGMAR1MAPTHCN4CYP3A4ALOX15 | |
| Cilobradine SCHEMBL30169956 | 0.73 | HCN4 (0.57) | SIGMAR1MAPTHCN4CYP3A4ALOX15 | |
| Cilobradine SCHEMBL1855245 | 0.73 | HCN4 (0.57) | SIGMAR1MAPTHCN4CYP3A4ALOX15 | |
| Cilobradine SCHEMBL9518220 | 0.72 | CYP3A4 (0.58) | SIGMAR1MAPTHCN4CYP3A4ALOX15 | |
| SCHEMBL9215483 | 0.72 | HTR1A (0.44) | ABCB1MAPTHCN4CYP3A4ALOX15 | |
| Cilobradine SCHEMBL9740702 | 0.72 | HCN4 (0.56) | SIGMAR1MAPTHCN4CYP3A4ALOX15 | |
| Cilobradine SCHEMBL2459609 | 0.72 | CYP3A4 (0.58) | SIGMAR1MAPTHCN4CYP3A4ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5175157-A | Cardiovascular disorders | BOEHRINGER INGELHEIM GMBH (DE) | 1992-12-29 | — | — | US | disclosed |