Known targets — ChEMBL curated mechanism
CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8
The experimentally established mechanism targets of Phloroglucinol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA5A | P35218 | 2/20 | 0.67 |
| ▸ | BACE1 | P56817 | 1/20 | 0.61 |
| ▸ | LMNA | P02545 | 3/20 | 0.57 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.55 |
| ▸ | MEN1 | O00255 | 2/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.55 |
| ▸ | HPGD | P15428 | 1/20 | 0.55 |
| ▸ | CA12 | O43570 | 5/20 | 0.53 |
| ▸ | CA2 | P00918 | 5/20 | 0.53 |
| ▸ | CA9 | Q16790 | 5/20 | 0.53 |
| ▸ | CA14 | Q9ULX7 | 5/20 | 0.53 |
| ▸ | CA1 | P00915 | 4/20 | 0.53 |
| ▸ | CA7 | P43166 | 4/20 | 0.53 |
| ▸ | FASN | P49327 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.44 |
| ▸ | LCK | P06239 | 1/20 | 0.42 |
| ▸ | HCAR1 | Q9BXC0 | 1/20 | 0.42 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.42 |
| ▸ | DRD3 | P35462 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Phloroglucinol SCHEMBL4159496 | 0.89 | CA5A (0.63) | CA5ABACE1LMNACYP3A4MEN1 | |
| Phloroglucinol SCHEMBL4901780 | 0.89 | CA5A (0.63) | CA5ABACE1LMNACYP3A4MEN1 | |
| Phloroglucinol SCHEMBL10695302 | 0.89 | CA5A (0.63) | CA5ABACE1LMNACYP3A4MEN1 | |
| Phloroglucinol SCHEMBL2526824 | 0.86 | CA5A (0.60) | CA5ABACE1LMNACYP3A4MEN1 | |
| SCHEMBL96189 | 0.81 | CA5A (1.00) | CA5ABACE1LMNACYP3A4MEN1 | |
| Phloroglucinol SCHEMBL28617918 | 0.81 | ALDH1A1 (0.59) | CA5ABACE1LMNACYP3A4MEN1 | |
| Resorcinol SCHEMBL8873830 | 0.81 | ALDH1A1 (0.71) | CA5ALMNACYP3A4KMT2ACA12 | |
| Phloroglucinol SCHEMBL22032286 | 0.79 | BACE1 (0.80) | CA5ABACE1LMNACYP3A4HPGD | |
| Water SCHEMBL3182721 | 0.78 | CA5A (0.94) | CA5ABACE1LMNACYP3A4MEN1 | |
| Orcinol SCHEMBL6749442 | 0.78 | ALDH1A1 (0.63) | CA5ABACE1LMNACYP3A4MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115386082-B | Porous covalent organic framework material containing cage-like unit structure and synthesis method thereof | 河南科技大学 | 2024-06-14 | — | — | CN | claimed |
| CN-115386082-A | Porous covalent organic framework material containing cage-shaped unit structure and synthesis method thereof | 河南科技大学 | 2022-11-25 | — | — | CN | claimed |
| CN-115386082-B | Porous covalent organic framework material containing cage-like unit structure and synthesis method thereof | 河南科技大学 | 2024-06-14 | — | — | CN | disclosed |
| CN-115386082-A | Porous covalent organic framework material containing cage-shaped unit structure and synthesis method thereof | 河南科技大学 | 2022-11-25 | — | — | CN | disclosed |
| US-5087548-A | POSITIVE TYPE RADIATION-SENSITIVE RESIN COMPOSITION | JAPAN SYNTHETIC RUBBER CO., INC. (JP) | 1992-02-11 | — | — | US | disclosed |