Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM5 | P08912 | 5/20 | 0.40 |
| ▸ | ADAM17 | P78536 | 2/20 | 0.38 |
| ▸ | ADAM10 | O14672 | 1/20 | 0.38 |
| ▸ | MMP1 | P03956 | 1/20 | 0.38 |
| ▸ | MMP2 | P08253 | 1/20 | 0.38 |
| ▸ | MMP14 | P50281 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | MDM2 | Q00987 | 3/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CNR1 | P21554 | 2/20 | 0.36 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.36 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.36 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9741939 | 0.92 | SMN1; SMN2 (0.43) | CHRM5HTTSMN1; SMN2MDM2CYP1A2 | |
| SCHEMBL9742447 | 0.90 | ADAM17 (0.40) | CHRM5ADAM17ADAM10MMP1MMP2 | |
| SCHEMBL9742194 | 0.88 | SMN1; SMN2 (0.43) | CHRM5HTTSMN1; SMN2MDM2CYP11B1 | |
| SCHEMBL9743860 | 0.87 | HTT (0.41) | CHRM5HTTSMN1; SMN2MDM2CYP1A2 | |
| SCHEMBL9743551 | 0.87 | PSEN1 (0.40) | CHRM5HTTSMN1; SMN2MDM2CYP1A2 | |
| SCHEMBL9743820 | 0.87 | CHRM5 (0.45) | CHRM5HTTSMN1; SMN2MDM2CYP1A2 | |
| SCHEMBL9743475 | 0.84 | CHRM5 (0.45) | CHRM5HTTSMN1; SMN2MDM2CYP2C9 | |
| SCHEMBL9742794 | 0.84 | HTT (0.40) | CHRM5HTTSMN1; SMN2CYP1A2CYP2D6 | |
| SCHEMBL9739646 | 0.82 | CHRM5 (0.42) | CHRM5AKR1B1 | |
| SCHEMBL9738615 | 0.82 | CHRM5 (0.46) | CHRM5HTTSMN1; SMN2MDM2CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1992016529-A1 | NOVEL ISOINDOLE DERIVATIVES AND MEDICAMENTS CONTAINING THEM | BOEHRINGER MANNHEIM GMBH (DE) | 1992-10-01 | — | — | WO | disclosed |