Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM5 | P08912 | 4/20 | 0.42 |
| ▸ | PARK7 | Q99497 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | GRIN1 | Q05586 | 3/20 | 0.39 |
| ▸ | GRIN2A | Q12879 | 3/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.36 |
| ▸ | HSD11B1 | P28845 | 3/20 | 0.36 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.35 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.35 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.35 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.35 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.35 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.35 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9741279 | 0.90 | PARK7 (0.43) | CHRM5PARK7MAPTGRIN1GRIN2A | |
| SCHEMBL9743423 | 0.84 | PARP1 (0.43) | CHRM5MAPTGRIN1GRIN2ANPC1 | |
| SCHEMBL9743860 | 0.84 | HTT (0.41) | CHRM5MAPTGRIN1GRIN2ANPC1 | |
| SCHEMBL9738615 | 0.84 | CHRM5 (0.46) | CHRM5MAPTNPC1POLBAKR1B1 | |
| SCHEMBL9739787 | 0.83 | CHRM5 (0.43) | CHRM5MAPTNPC1POLB | |
| SCHEMBL9743255 | 0.82 | CHRM5 (0.40) | CHRM5AKR1B1 | |
| SCHEMBL9743551 | 0.82 | PSEN1 (0.40) | CHRM5MAPTAKR1B1PSEN1PSEN2 | |
| SCHEMBL9743611 | 0.81 | PARP1 (0.46) | CHRM5GRIN1GRIN2AHSD11B1 | |
| SCHEMBL9743467 | 0.76 | PARP1 (0.43) | CHRM5MAPTGRIN1GRIN2ANPC1 | |
| SCHEMBL9743436 | 0.76 | GRIN1 (0.39) | CHRM5MAPTGRIN1GRIN2ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1992016529-A1 | NOVEL ISOINDOLE DERIVATIVES AND MEDICAMENTS CONTAINING THEM | BOEHRINGER MANNHEIM GMBH (DE) | 1992-10-01 | — | — | WO | disclosed |