SCHEMBL974380

SCHEMBL974380

Cc1ccc(CNS(=O)(=O)c2ccc(-c3cc(C(F)(F)F)no3)s2)o1

nearest known ligand 0.48

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
MAPT P10636 13/20 0.48
POLB P06746 4/20 0.46
TP53 P04637 5/20 0.44
RXFP1 Q9HBX9 1/20 0.43
NPC1 O15118 2/20 0.38
RAB9A P51151 1/20 0.38
KMT2A Q03164 2/20 0.38
LMNA P02545 1/20 0.38
MEN1 O00255 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL972208 0.86 MAPT (0.64) MAPTPOLBTP53NPC1RAB9A
SCHEMBL971957 0.84 POLB (0.65) MAPTPOLBTP53RXFP1KMT2A
SCHEMBL3401284 0.72 MAPT (0.44) MAPTPOLBTP53NPC1RAB9A
SCHEMBL12932090 0.71 POLB (0.40) MAPTPOLBTP53NPC1RAB9A
SCHEMBL6372334 0.69 RXFP1 (0.44) MAPTPOLBTP53RXFP1RAB9A
SCHEMBL13742883 0.68 TP53 (0.41) MAPTPOLBTP53RXFP1NPC1
SCHEMBL13398958 0.65 ADAMTS5 (0.61) MAPT
SCHEMBL12169323 0.64 KMT2A (0.57) MAPTPOLBKMT2ALMNAMEN1
SCHEMBL972405 0.62 KMT2A (0.59) MAPTTP53NPC1RAB9AKMT2A
SCHEMBL13814487 0.60 KMT2A (0.43) MAPTPOLBTP53KMT2ALMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20110015065-A1 Substituted Sulfonic Acid Amide Compounds BASF SE (DE) 2011-01-20 US claimed
US-20110015065-A1 Substituted Sulfonic Acid Amide Compounds BASF SE (DE) 2011-01-20 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110015065-A1 Substituted Sulfonic Acid Amide Compounds STS, NAPA, NAAA MAPT 3640/4885POLB 4080/4885TP53 783/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.