Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.52 |
| ▸ | POLB | P06746 | 2/20 | 0.52 |
| ▸ | HTT | P42858 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | MGAM | O43451 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | SI | P14410 | 1/20 | 0.48 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.48 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.48 |
| ▸ | CA1 | P00915 | 2/20 | 0.46 |
| ▸ | CA2 | P00918 | 2/20 | 0.46 |
| ▸ | CA4 | P22748 | 1/20 | 0.46 |
| ▸ | CA5A | P35218 | 1/20 | 0.46 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.46 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.45 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8707903 | 0.84 | KDM4E (0.67) | ALDH1A1POLBHTTMEN1LMNA | |
| SCHEMBL9018567 | 0.83 | ALDH1A1 (0.61) | ALDH1A1POLBMEN1LMNAKMT2A | |
| SCHEMBL2213286 | 0.80 | ALDH1A1 (0.59) | ALDH1A1POLBMEN1LMNAKMT2A | |
| SCHEMBL3962310 | 0.80 | KDM4E (0.59) | ALDH1A1POLBHTTMEN1LMNA | |
| SCHEMBL11088257 | 0.78 | SMN1; SMN2 (0.60) | ALDH1A1LMNAALOX12KMT2AKDM4E | |
| SCHEMBL11091755 | 0.78 | KDM4E (0.50) | ALDH1A1HTTMEN1LMNAKMT2A | |
| SCHEMBL17948201 | 0.78 | ALDH1A1 (0.57) | ALDH1A1POLBMEN1LMNAKMT2A | |
| SCHEMBL174599 | 0.78 | KDM4E (0.64) | ALDH1A1HTTMEN1LMNAKMT2A | |
| SCHEMBL11873113 | 0.77 | ALDH1A1 (0.65) | ALDH1A1POLBMEN1LMNAKMT2A | |
| SCHEMBL3830634 | 0.77 | RAB9A (0.46) | ALDH1A1POLBMEN1KMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 113 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109593088-B | Azabicyclo derivatives, their preparation and use | 华东理工大学 | 2022-03-25 | — | — | CN | disclosed |
| CN-106817899-B | Spiroheptane as ROCK inhibitor | 百时美施贵宝公司 | 2021-03-09 | — | — | CN | disclosed |
| CN-111233840-A | Quinoxaline derivative and application thereof in organic light-emitting device | 北京鼎材科技有限公司 | 2020-06-05 | — | — | CN | disclosed |
| EP-3252050-B1 | PHTHALAZINONES AND ISOQUINOLINONES AS ROCK INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2020-02-26 | — | — | EP | disclosed |
| EP-3252050-B1 | PHTHALAZINONES AND ISOQUINOLINONES AS ROCK INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2020-02-26 | — | — | EP | disclosed |
| US-10385026-B2 | Phthalazinones and isoquinolinones as rock inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2019-08-20 | — | — | US | disclosed |
| US-10385026-B2 | Phthalazinones and isoquinolinones as rock inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2019-08-20 | — | — | US | disclosed |
| EP-3169682-B1 | SPIROCYCLOHEPTANES AS INHIBITORS OF ROCK | BRISTOL MYERS SQUIBB CO (US) | 2018-12-26 | — | — | EP | disclosed |
| US-20180162823-A1 | PHTHALAZINONES AND ISOQUINOLINONES AS ROCK INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2018-06-14 | — | — | US | disclosed |
| US-20180162823-A1 | PHTHALAZINONES AND ISOQUINOLINONES AS ROCK INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2018-06-14 | — | — | US | disclosed |
| EP-1506200-A2 | NOVEL DIAZABICYCLIC BIARYL DERIVATIVES | NEUROSEARCH A/S (DK) | 2005-02-16 | — | — | EP | disclosed |
| WO-2004029053-A1 | NOVEL 1,4-DIAZABICYCLOALKANE DERIVATIVES, THEIR PREPARATION AND USE | NEUROSEARCH A/S (DK) | 2004-04-08 | — | — | WO | disclosed |
| WO-2003094831-A2 | NOVEL DIAZABICYCLIC BIARYL DERIVATIVES | NEUROSEARCH A/S (DK) | 2003-11-20 | — | — | WO | disclosed |
| EP-0384250-A2 | Sulfonylated azinyliminoheteroazole, process and intermediates for their preparation and their use as herbicides | BAYER AG (DE) | 1990-08-29 | — | — | EP | disclosed |
| EP-0384244-A1 | Sulfonylimino-azinyl heteroazoles, method and intermediates for their preparation and their use as herbicides | BAYER AG (DE) | 1990-08-29 | — | — | EP | disclosed |
| US-4596802-A | Nervous system disorders | SANOFI (FR) | 1986-06-24 | — | — | US | disclosed |
| EP-0060426-B1 | N-(2,2,2-TRIFLUOROETHYL)-N-ALKYL-AZOLYLOXYACETIC-ACID AMIDES, THEIR PREPARATION AND USE AS HERBICIDES AND INTERMEDIATES FOR THEIR PREPARATION | BAYER AG (DE) | 1986-04-23 | — | — | EP | disclosed |
| US-4465504-A | Herbicidally active novel N-(2,2,2-trifluoroethyl)-N-alkyl-azolyloxyacetic acid amides and intermediates therefor | BAYER AKTIENGESELLSCHAFT (DE) | 1984-08-14 | — | — | US | disclosed |
| EP-0060426-A2 | N-(2,2,2-trifluoroethyl)-N-alkyl-azolyloxyacetic-acid amides, their preparation and use as herbicides and intermediates for their preparation | BAYER AG (DE) | 1982-09-22 | — | — | EP | disclosed |
| US-3959301-A | HERBICIDE | GULF RESEARCH & DEVELOPMENT COMPANY (US) | 1976-05-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180162823-A1 | PHTHALAZINONES AND ISOQUINOLINONES AS ROCK INHIBITORS | MYLK, MYLK2, ROCK1 | ALDH1A1 2535/4885POLB 3891/4885HTT 2375/4885 |
| US-10385026-B2 | Phthalazinones and isoquinolinones as rock inhibitors | MYLK, MYLK2, ROCK1 | ALDH1A1 2535/4885POLB 3891/4885HTT 2375/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.