Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CREBBP | Q92793 | 4/20 | 0.41 |
| ▸ | BRPF1 | P55201 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 5/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | TGM2 | P21980 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | IDO1 | P14902 | 1/20 | 0.38 |
| ▸ | BRD4 | O60885 | 4/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | EP300 | Q09472 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | HBB | P68871 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6466780 | 0.76 | LMNA (0.36) | LMNATSHRTNKS2MAPTALDH1A1 | |
| SCHEMBL16163145 | 0.74 | LMNA (0.43) | LMNATSHRTNKS2MAPTALDH1A1 | |
| SCHEMBL27513787 | 0.71 | EDNRB (0.44) | LMNAMAPTALDH1A1HTTALOX15 | |
| SCHEMBL13847518 | 0.71 | CREBBP (0.55) | CREBBPBRPF1LMNATSHRTNKS2 | |
| SCHEMBL6684295 | 0.70 | MAPT (0.46) | LMNAMAPTALDH1A1HTTSMN1; SMN2 | |
| SCHEMBL13603804 | 0.68 | EDNRB (0.48) | LMNAMAPTALDH1A1HTTALOX15 | |
| SCHEMBL3030100 | 0.68 | MAOA (0.42) | LMNATSHRTNKS2MAPTALDH1A1 | |
| SCHEMBL10411385 | 0.68 | HTT (0.36) | CREBBPLMNATSHRMAPTALDH1A1 | |
| SCHEMBL31739367 | 0.67 | TSHR (0.47) | LMNATSHRTNKS2ALDH1A1SMN1; SMN2 | |
| SCHEMBL19492450 | 0.67 | TSHR (0.47) | LMNATSHRTNKS2ALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0494978-A1 | HETEROCYCLIC COMPOUNDS. | WYETH JOHN & BROTHER LTD (GB) | 1992-07-22 | — | — | EP | disclosed |
| WO-1991005783-A1 | HETEROCYCLIC COMPOUNDS | JOHN WYETH & BROTHER LIMITED (GB) | 1991-05-02 | — | — | WO | disclosed |