SCHEMBL9745362

SCHEMBL9745362

CCCCCCCCCCCCCCCCCCS(=O)(=O)c1ccc(CBr)cc1

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
THRB P10828 4/20 0.50
THRA P10827 2/20 0.50
MCHR1 Q99705 1/20 0.50
CA2 P00918 5/20 0.49
ALDH1A1 P00352 1/20 0.47
CYP3A4 P08684 1/20 0.47
CYP2C9 P11712 1/20 0.47
CYP2C19 P33261 1/20 0.47
SMN1; SMN2 Q16637 1/20 0.46
PSIP1 O75475 1/20 0.42
CA12 O43570 2/20 0.40
CA1 P00915 2/20 0.40
CA9 Q16790 1/20 0.40
AKT1 P31749 1/20 0.40
GSR P00390 1/20 0.40
TXNRD1 Q16881 1/20 0.40
MMP13 P45452 2/20 0.39
KCNH2 Q12809 1/20 0.39
S1PR2 O95136 1/20 0.39
S1PR1 P21453 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9574391 1.00 THRB (0.50) THRBTHRAMCHR1CA2ALDH1A1
SCHEMBL1941301 0.85 PSIP1 (0.47) CA2ALDH1A1CYP3A4CYP2C9CYP2C19
SCHEMBL14379397 0.82 PLCG1 (0.59) THRBTHRAMCHR1CA2ALDH1A1
SCHEMBL10300267 0.82 THRB (0.55) THRBTHRAMCHR1CA2ALDH1A1
SCHEMBL5593862 0.81 PSIP1 (0.67) THRBTHRAMCHR1CA2ALDH1A1
SCHEMBL9099326 0.80 ALDH1A1 (0.74) THRBTHRAMCHR1CA2ALDH1A1
SCHEMBL9099947 0.80 ALDH1A1 (0.74) THRBTHRAMCHR1CA2ALDH1A1
SCHEMBL9103003 0.80 ALDH1A1 (0.74) THRBTHRAMCHR1CA2ALDH1A1
SCHEMBL8340902 0.80 ALDH1A1 (0.74) THRBTHRAMCHR1CA2ALDH1A1
SCHEMBL14543475 0.80 PLCG1 (0.55) THRBTHRAMCHR1CA2ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0313474-B1 AN OPTICAL ARTICLE EXHIBITING A HIGH LEVEL OF SECOND ORDER POLARIZATION SUSCEPTIBILITY EASTMAN KODAK COMPANY (a New Jersey corporation) (US) 1992-12-23 EP disclosed
EP-0313474-A2 An optical article exhibiting a high level of second order polarization susceptibility EASTMAN KODAK COMPANY (a New Jersey corporation) (US) 1989-04-26 EP disclosed
US-4792208-A POLAR ALIGNED NONCENTROSYMMETRIC MOLECULAR DIPOLES; SULFONYL MOIETY AS ELECTRON ACCEPTOR EASTMAN KODAK COMPANY (US) 1988-12-20 US disclosed