Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 9/20 | 0.57 |
| ▸ | BRD4 | O60885 | 1/20 | 0.46 |
| ▸ | HDAC8 | Q9BY41 | 8/20 | 0.45 |
| ▸ | HDAC2 | Q92769 | 7/20 | 0.45 |
| ▸ | HDAC6 | Q9UBN7 | 7/20 | 0.45 |
| ▸ | SERPINE1 | P05121 | 2/20 | 0.45 |
| ▸ | PRSS12 | P56730 | 1/20 | 0.45 |
| ▸ | HDAC3 | O15379 | 6/20 | 0.44 |
| ▸ | HDAC4 | P56524 | 6/20 | 0.44 |
| ▸ | HDAC7 | Q8WUI4 | 6/20 | 0.44 |
| ▸ | HDAC10 | Q969S8 | 6/20 | 0.44 |
| ▸ | HDAC11 | Q96DB2 | 6/20 | 0.44 |
| ▸ | HDAC9 | Q9UKV0 | 6/20 | 0.44 |
| ▸ | HDAC5 | Q9UQL6 | 6/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | GFER | P55789 | 1/20 | 0.42 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL975822 | 0.91 | BRD4 (0.52) | HDAC1BRD4HDAC4MEN1KMT2A | |
| SCHEMBL1082274 | 0.86 | BRD4 (0.50) | HDAC1BRD4MEN1KMT2AGAA | |
| SCHEMBL978418 | 0.84 | HDAC1 (0.59) | HDAC1BRD4KMT2A | |
| SCHEMBL3984770 | 0.80 | SERPINE1 (0.58) | HDAC1BRD4HDAC8HDAC6SERPINE1 | |
| SCHEMBL4087564 | 0.78 | SERPINE1 (0.51) | BRD4HDAC8HDAC6SERPINE1HDAC3 | |
| SCHEMBL3979859 | 0.77 | ALDH1A1 (0.51) | BRD4HDAC8HDAC6SERPINE1PRSS12 | |
| SCHEMBL3982480 | 0.77 | SERPINE1 (0.51) | BRD4HDAC8HDAC6SERPINE1HDAC3 | |
| SCHEMBL3983520 | 0.77 | SERPINE1 (0.48) | BRD4HDAC8HDAC6SERPINE1HDAC3 | |
| SCHEMBL3980708 | 0.77 | SERPINE1 (0.52) | HDAC1BRD4HDAC8HDAC6SERPINE1 | |
| SCHEMBL14079336 | 0.77 | SERPINE1 (0.50) | BRD4HDAC8HDAC6SERPINE1HDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8673911-B2 | Inhibitors of histone deacetylase | METHYLGENE INC. (CA) | 2014-03-18 | — | — | US | disclosed |
| US-8673911-B2 | Inhibitors of histone deacetylase | METHYLGENE INC. (CA) | 2014-03-18 | — | — | US | disclosed |
| US-20140045850-A1 | INHIBITORS OF HISTONE DEACETYLASE | METHYLGENE INC. (CA) | 2014-02-13 | — | — | US | disclosed |
| US-20140045850-A1 | INHIBITORS OF HISTONE DEACETYLASE | METHYLGENE INC. (CA) | 2014-02-13 | — | — | US | disclosed |
| US-20110021771-A1 | INHIBITORS OF HISTONE DEACETYLASE | METHYLGENE INC. (CA) | 2011-01-27 | — | — | US | disclosed |
| US-20110021771-A1 | INHIBITORS OF HISTONE DEACETYLASE | METHYLGENE INC. (CA) | 2011-01-27 | — | — | US | disclosed |
| EP-2217588-A1 | INHIBITORS OF HISTONE DEACETYLASE | Methylgene, Inc. (CA) | 2010-08-18 | — | — | EP | disclosed |
| WO-2009055917-A1 | INHIBITORS OF HISTONE DEACETYLASE | METHYLGENE INC. (CA) | 2009-05-07 | — | — | WO | disclosed |
| WO-2009055917-A1 | INHIBITORS OF HISTONE DEACETYLASE | METHYLGENE INC. (CA) | 2009-05-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110021771-A1 | INHIBITORS OF HISTONE DEACETYLASE | HDAC1, HDAC11, HDAC3 | HDAC1 1/4885BRD4 683/4885HDAC8 8/4885 |
| US-20140045850-A1 | INHIBITORS OF HISTONE DEACETYLASE | HDAC1, HDAC11, HDAC3 | HDAC1 1/4885BRD4 683/4885HDAC8 8/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.