Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 3/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.37 |
| ▸ | CHRM5 | P08912 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | CYP11B2 | P19099 | 3/20 | 0.36 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | PARP1 | P09874 | 1/20 | 0.34 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9742428 | 0.91 | LMNA (0.37) | SMN1; SMN2HTTLMNANPSR1CHRM5 | |
| SCHEMBL9742794 | 0.90 | HTT (0.40) | SMN1; SMN2HTTAKR1B1LMNANPSR1 | |
| SCHEMBL9742194 | 0.87 | SMN1; SMN2 (0.43) | SMN1; SMN2HTTAKR1B1LMNANPSR1 | |
| SCHEMBL9743860 | 0.87 | HTT (0.41) | SMN1; SMN2HTTAKR1B1LMNANPSR1 | |
| SCHEMBL9743551 | 0.86 | PSEN1 (0.40) | SMN1; SMN2HTTAKR1B1LMNANPSR1 | |
| SCHEMBL9739723 | 0.85 | LMNA (0.46) | SMN1; SMN2HTTLMNANPSR1CHRM5 | |
| SCHEMBL9742640 | 0.85 | CHRM5 (0.46) | CHRM5KMT2APARP1MDM2 | |
| SCHEMBL9741939 | 0.84 | SMN1; SMN2 (0.43) | SMN1; SMN2HTTAKR1B1LMNANPSR1 | |
| SCHEMBL9743002 | 0.83 | CHRM5 (0.46) | CHRM5MAPT | |
| SCHEMBL9743423 | 0.82 | PARP1 (0.43) | SMN1; SMN2LMNANPSR1CHRM5KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1992016529-A1 | NOVEL ISOINDOLE DERIVATIVES AND MEDICAMENTS CONTAINING THEM | BOEHRINGER MANNHEIM GMBH (DE) | 1992-10-01 | — | — | WO | disclosed |