Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.46 |
| ▸ | PARP1 | P09874 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | CHRM5 | P08912 | 5/20 | 0.38 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.37 |
| ▸ | BACE1 | P56817 | 1/20 | 0.36 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.36 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.36 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.36 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9742428 | 0.85 | LMNA (0.37) | LMNANPSR1PARP1MAPTHDAC4 | |
| SCHEMBL9745487 | 0.85 | SMN1; SMN2 (0.38) | LMNANPSR1PARP1NPC1POLB | |
| SCHEMBL9739497 | 0.85 | MAPT (0.46) | LMNANPSR1PARP1NPC1POLB | |
| SCHEMBL9740279 | 0.85 | HTT (0.47) | LMNANPSR1NPC1POLBMAPT | |
| SCHEMBL9739787 | 0.85 | CHRM5 (0.43) | NPC1POLBMAPTKMT2AMEN1 | |
| SCHEMBL9742140 | 0.84 | CHRM5 (0.49) | PARP1KMT2ACHRM5BACE1OPRM1 | |
| SCHEMBL9743423 | 0.83 | PARP1 (0.43) | LMNANPSR1PARP1NPC1POLB | |
| SCHEMBL9743467 | 0.83 | PARP1 (0.43) | LMNAPARP1NPC1POLBMAPT | |
| SCHEMBL9738601 | 0.81 | CHRM5 (0.53) | NPC1POLBMAPTKMT2AMEN1 | |
| SCHEMBL9740111 | 0.81 | SLC6A2 (0.43) | LMNANPSR1NPC1POLBKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1992016529-A1 | NOVEL ISOINDOLE DERIVATIVES AND MEDICAMENTS CONTAINING THEM | BOEHRINGER MANNHEIM GMBH (DE) | 1992-10-01 | — | — | WO | disclosed |