Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.47 |
| ▸ | SMYD3 | Q9H7B4 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 3/20 | 0.46 |
| ▸ | RAB9A | P51151 | 3/20 | 0.46 |
| ▸ | PLAU | P00749 | 1/20 | 0.46 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.46 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 2/20 | 0.46 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.44 |
| ▸ | TAOK3 | Q9H2K8 | 1/20 | 0.44 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | CASP3 | P42574 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13830464 | 0.89 | KMT2A (0.53) | KMT2ASMYD3NPC1RAB9AOPRM1 | |
| SCHEMBL14157778 | 0.81 | HPGDS (0.55) | KMT2ANPC1RAB9APLAUTP53 | |
| SCHEMBL5712105 | 0.78 | ALDH1A1 (0.71) | KMT2ASMYD3NPC1RAB9APLAU | |
| SCHEMBL8384926 | 0.77 | ALDH1A1 (0.67) | KMT2ASMYD3NPC1RAB9AMAPT | |
| SCHEMBL10539670 | 0.77 | ALDH1A1 (0.50) | KMT2ASMYD3NPC1RAB9APLAU | |
| SCHEMBL9746364 | 0.76 | RARB (0.67) | KMT2AALDH1A1MEN1 | |
| SCHEMBL9747829 | 0.76 | RARB (0.56) | KMT2ACYP17A1ALDH1A1MEN1 | |
| SCHEMBL3949393 | 0.75 | HDAC3 (0.62) | KMT2ANPC1RAB9ATP53MAPT | |
| Hydrochloric Acid SCHEMBL6163330 | 0.74 | ITGB3 (0.50) | PLAU | |
| SCHEMBL1787705 | 0.73 | HRH3 (0.61) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0220118-B1 | BICYCLIC NAPHTHALENIC DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE IN HUMAN AND VETERINARY MEDICINE AND COSMETICS | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES GALDERMA - CIRD GALDERMA (FR) | 1992-01-02 | — | — | EP | claimed |