Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.58 |
| ▸ | DDAH1 | O94760 | 1/20 | 0.54 |
| ▸ | NPC1 | O15118 | 1/20 | 0.54 |
| ▸ | RAB9A | P51151 | 1/20 | 0.54 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.51 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4117396 | 0.84 | POLB (0.66) | POLBDDAH1NPC1RAB9APDE10A | |
| SCHEMBL4619202 | 0.81 | POLB (0.62) | POLBDDAH1NPC1RAB9APDE10A | |
| SCHEMBL8974221 | 0.79 | POLB (0.58) | POLBDDAH1NPC1RAB9APDE10A | |
| SCHEMBL29620366 | 0.79 | POLB (0.72) | POLBDDAH1NPC1RAB9APDE10A | |
| SCHEMBL524002 | 0.79 | POLB (0.72) | POLBDDAH1NPC1RAB9APDE10A | |
| SCHEMBL6756267 | 0.78 | POLB (0.72) | POLBDDAH1NPC1RAB9APDE10A | |
| SCHEMBL11842747 | 0.78 | POLB (0.50) | POLBDDAH1NPC1RAB9APDE10A | |
| SCHEMBL230157 | 0.78 | POLB (0.84) | POLBDDAH1NPC1RAB9APDE10A | |
| SCHEMBL11636651 | 0.77 | POLB (0.56) | POLBDDAH1NPC1RAB9APDE10A | |
| Hydrochloric Acid SCHEMBL28373229 | 0.77 | POLB (0.70) | POLBDDAH1NPC1RAB9APDE10A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0222283-B1 | AMINO-ACID DERIVATIVES | MERCK PATENT GmbH (DE) | 1992-12-30 | — | — | EP | disclosed |
| US-4721776-A | Amino acid derivatives | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1988-01-26 | — | — | US | disclosed |
| EP-0222283-A2 | Amino-acid derivatives | MERCK PATENT GmbH (DE) | 1987-05-20 | — | — | EP | disclosed |