Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RARB | P10826 | 11/20 | 0.60 |
| ▸ | RARG | P13631 | 11/20 | 0.60 |
| ▸ | RARA | P10276 | 10/20 | 0.60 |
| ▸ | CYP26A1 | O43174 | 4/20 | 0.60 |
| ▸ | CYP26B1 | Q9NR63 | 1/20 | 0.60 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.53 |
| ▸ | RXRA | P19793 | 2/20 | 0.50 |
| ▸ | RXRB | P28702 | 2/20 | 0.50 |
| ▸ | RXRG | P48443 | 2/20 | 0.50 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.49 |
| ▸ | LCK | P06239 | 1/20 | 0.43 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
| ▸ | HGFAC | Q04756 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8523097 | 0.84 | RARB (0.83) | RARBRARGRARACYP26A1CYP26B1 | |
| SCHEMBL10540743 | 0.83 | RARB (0.63) | RARBRARGRARACYP26A1CYP26B1 | |
| SCHEMBL7422927 | 0.81 | RXRA (0.70) | RARBRARGRARACYP26A1CYP26B1 | |
| SCHEMBL9746786 | 0.81 | RARB (0.74) | RARBRARGRARACYP26A1CYP26B1 | |
| SCHEMBL7899482 | 0.81 | RXRA (0.61) | RARBRARGRARACYP26A1CYP26B1 | |
| SCHEMBL2788640 | 0.81 | CYP3A4 (0.70) | RARBRARGRARACYP26A1CYP26B1 | |
| SCHEMBL9747829 | 0.80 | RARB (0.56) | RARBRARGRARACYP26A1CYP26B1 | |
| SCHEMBL9746239 | 0.80 | PTPN11 (0.48) | RARBRARGRARACYP26A1CYP26B1 | |
| SCHEMBL18775432 | 0.80 | RARB (0.73) | RARBRARGRARACYP26A1CYP26B1 | |
| SCHEMBL9748144 | 0.77 | RARB (0.60) | RARBRARGRARACYP26A1CYP26B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0220118-B1 | BICYCLIC NAPHTHALENIC DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE IN HUMAN AND VETERINARY MEDICINE AND COSMETICS | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES GALDERMA - CIRD GALDERMA (FR) | 1992-01-02 | — | — | EP | claimed |