Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN11 | Q06124 | 2/20 | 0.48 |
| ▸ | CYP26A1 | O43174 | 3/20 | 0.46 |
| ▸ | RARA | P10276 | 1/20 | 0.46 |
| ▸ | RARB | P10826 | 1/20 | 0.46 |
| ▸ | RARG | P13631 | 1/20 | 0.46 |
| ▸ | CYP26B1 | Q9NR63 | 1/20 | 0.46 |
| ▸ | LCK | P06239 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.41 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.40 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.40 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 2/20 | 0.40 |
| ▸ | CA2 | P00918 | 2/20 | 0.40 |
| ▸ | CA12 | O43570 | 1/20 | 0.40 |
| ▸ | CA7 | P43166 | 1/20 | 0.40 |
| ▸ | XDH | P47989 | 1/20 | 0.40 |
| ▸ | CA9 | Q16790 | 1/20 | 0.40 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10355823 | 0.90 | CYP3A4 (0.43) | CYP26A1RARBRARGCYP3A4ALDH1A1 | |
| SCHEMBL9746735 | 0.85 | RARB (0.63) | CYP26A1RARARARBRARGCYP26B1 | |
| SCHEMBL10544739 | 0.83 | RARB (0.48) | CYP26A1RARARARBRARGCYP26B1 | |
| SCHEMBL9746813 | 0.81 | RARB (0.43) | CYP26A1RARARARBRARGCYP26B1 | |
| SCHEMBL9747005 | 0.80 | RARB (0.60) | PTPN11CYP26A1RARARARBRARG | |
| SCHEMBL9185753 | 0.80 | CYP3A4 (0.50) | CYP26A1CYP3A4ALDH1A1CA1CA2 | |
| SCHEMBL9748837 | 0.78 | CYP26B1 (0.46) | CYP26A1RARARARBRARGCYP26B1 | |
| SCHEMBL9822364 | 0.77 | RARB (0.42) | CYP26A1RARARARBRARGCYP26B1 | |
| SCHEMBL8522801 | 0.77 | RXRA (0.60) | CYP26A1RARARARBRARGCYP26B1 | |
| SCHEMBL29365729 | 0.75 | PTPN11 (0.68) | PTPN11LCKCYP19A1CYP11B1CYP11B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0220118-B1 | BICYCLIC NAPHTHALENIC DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE IN HUMAN AND VETERINARY MEDICINE AND COSMETICS | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES GALDERMA - CIRD GALDERMA (FR) | 1992-01-02 | — | — | EP | claimed |