Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.35 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.34 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | HTR2A | P28223 | 3/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28805536 | 0.76 | TAAR1 (0.37) | TAAR1ADRA2AADRA2CCYP2D6LMNA | |
| SCHEMBL10348035 | 0.76 | LMNA (0.46) | TAAR1ADRA2AADRA2CCYP2D6LMNA | |
| SCHEMBL12950121 | 0.76 | CYP2D6 (0.39) | TAAR1ADRA2AADRA2CCYP2D6LMNA | |
| SCHEMBL12950125 | 0.76 | CYP2D6 (0.39) | TAAR1ADRA2AADRA2CCYP2D6LMNA | |
| SCHEMBL3246544 | 0.75 | TRPA1 (0.45) | TDP1TAAR1ADRA2AADRA2CCYP2D6 | |
| SCHEMBL908216 | 0.72 | TAAR1 (0.50) | TAAR1ADRA2AADRA2CCYP2D6LMNA | |
| SCHEMBL315078 | 0.71 | HTR2A (0.41) | TDP1LMNAHTR2A | |
| SCHEMBL27633315 | 0.69 | HTR2A (0.40) | TDP1CYP2D6LMNAKDM4EHTR2A | |
| SCHEMBL7366231 | 0.69 | ALDH1A1 (0.39) | TAAR1CYP2D6LMNAKDM4EHTR2A | |
| SCHEMBL599878 | 0.68 | TAAR1 (0.48) | TAAR1ADRA2AADRA2CCYP2D6LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0204285-B1 | IMIDAZOHETEROCYCLIC COMPOUNDS PROCESSES FOR PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1992-01-15 | — | — | EP | disclosed |
| US-4725601-A | Certain imidazo[1,2-a]pyridines useful in the treatment of ulcers | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1988-02-16 | — | — | US | disclosed |
| EP-0204285-A1 | Imidazoheterocyclic compounds processes for preparation thereof and pharmaceutical compositions comprising them | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1986-12-10 | — | — | EP | disclosed |