Mesodihydroguaiaretic Acid

Mesodihydroguaiaretic Acid

SCHEMBL974725

COc1cc(C[C@@H](C)[C@@H](C)Cc2ccc(O)c(OC)c2)ccc1O

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
FOS P01100 2/20 1.00
TTR P02766 2/20 1.00
JUN P05412 2/20 1.00
NR3C1 P04150 2/20 1.00
HSD17B1 P14061 2/20 1.00
HSD17B2 P37059 2/20 1.00
ALOX15 P16050 6/20 0.90
ALOX12 P18054 6/20 0.90
MAPT P10636 2/20 0.71
GAA P10253 2/20 0.71
ATM Q13315 1/20 0.71
CYP3A4 P08684 4/20 0.70
MMP1 P03956 1/20 0.70
ALDH1A1 P00352 4/20 0.63
MAPK1 P28482 3/20 0.63
KDM4E B2RXH2 2/20 0.63
MEN1 O00255 2/20 0.63
ESR1 P03372 2/20 0.63
TP53 P04637 2/20 0.63
HPGD P15428 2/20 0.63

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Dihydroguaiaretic Acid SCHEMBL9087980 1.00 FOS (1.00) FOSTTRJUNNR3C1HSD17B1
SCHEMBL13309003 0.95 ALOX15 (1.00) FOSTTRJUNNR3C1HSD17B1
SCHEMBL2390 0.95 FOS (0.90) FOSTTRJUNNR3C1HSD17B1
SCHEMBL29929344 0.95 ALOX15 (1.00) FOSTTRJUNNR3C1HSD17B1
SCHEMBL31237435 0.95 FOS (0.90) FOSTTRJUNNR3C1HSD17B1
SCHEMBL16917560 0.95 FOS (0.90) FOSTTRJUNNR3C1HSD17B1
SCHEMBL29794171 0.95 ALOX15 (1.00) FOSTTRJUNNR3C1HSD17B1
SCHEMBL4639890 0.95 ALOX15 (1.00) FOSTTRJUNNR3C1HSD17B1
SCHEMBL16151511 0.92 FOS (0.84) FOSTTRJUNNR3C1HSD17B1
Mesodihydroguaiaretic Acid SCHEMBL4852003 0.92 FOS (0.84) FOSTTRJUNNR3C1HSD17B1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 352 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250144164-A1 COMPOSITIONS, METHODS, AND MEDICAL COMPOSITIONS FOR TREATMENT OF AND MAINTAINING THE HEALTH OF THE LIVER UNIGEN, INC. (US) 2025-05-08 US claimed
CN-119859620-A Polypeptide for catalyzing hydroxylation of lignans, encoding gene, preparation method and application 中国医学科学院药用植物研究所 2025-04-22 CN claimed
US-20240366544-A1 REGULATION OF MUTANT TERT BY BRAF V600E/MAP KINASE PATHWAY THROUGH FOS/GABP IN HUMAN CANCER UNIV JOHNS HOPKINS (US) 2024-11-07 US claimed
CN-118304334-A Preparation and application of traditional Chinese medicine fructus rhodomyrti liver protection active ingredient 北京工业大学 2024-07-09 CN claimed
US-11911356-B2 Regulation of mutant TERT by BRAF V600E/map kinase pathway through FOS/GABP in human cancer THE JOHNS HOPKINS UNIVERSITY (US) 2024-02-27 US claimed
CN-116327681-A Gel formulations comprising substituted imidazo [1, 2-alpha ] pyridin-2-ylamine hydrochloride hydrate 上海复旦张江生物医药股份有限公司 2023-06-27 CN claimed
CN-112812358-B Reclaimed rubber 财团法人工业技术研究院 2023-05-09 CN claimed
CN-114452271-B Application of diarylbutane compounds in preparation of drugs for inhibiting new coronavirus 中国医学科学院药用植物研究所 2023-03-14 CN claimed
CN-113243420-B Fruit wax material for preventing sorbitol candy core from digestion and transportation and preparation and application method thereof 浙江大学 2022-10-21 CN claimed
CN-110066848-B Method for researching cytological influence of exogenous ABA treatment on tomato pollen maturation 临沂大学 2022-06-07 CN claimed
EP-0759750-A4 COMPOSITIONS FOR TREATMENT OF CHRONIC INFLAMMATORY DISEASES SHAPIRO HOWARD K (US) 1998-05-27 EP claimed
EP-0592622-B1 EXTENSION OF EDIBLE OIL LIFETIME USING ACTIVATED CARBONS CALGON CARBON CORP (US) 1997-06-25 EP claimed
EP-0759750-A1 COMPOSITIONS FOR TREATMENT OF CHRONIC INFLAMMATORY DISEASES SHAPIRO, Howard, K. (US) 1997-03-05 EP claimed
WO-1995031194-A1 COMPOSITIONS FOR TREATMENT OF CHRONIC INFLAMMATORY DISEASES SHAPIRO HOWARD K (US) 1995-11-23 WO claimed
EP-0290442-A4 PHARMACOLOGICALLY ACTIVE COMPOUNDS AND MIXTURES THEREOF, ORGANIC COMPOSITIONS AND METAL SALTS. CHEMEX PHARMACEUTICALS INC (US) 1990-07-03 EP claimed
EP-0290442-A1 PHARMACOLOGICALLY ACTIVE COMPOUNDS AND MIXTURES THEREOF, ORGANIC COMPOSITIONS AND METAL SALTS CHEMEX PHARMACEUTICALS, INC. (US) 1988-11-17 EP claimed
US-4774229-A ANTITUMOR AGENTS, SKIN DISORDERS, CANCER TREATMENT CHEMEX PHARMACEUTICALS, INC. (US) 1988-09-27 US claimed
WO-1988003805-A1 PHARMACOLOGICALLY ACTIVE COMPOUNDS AND MIXTURES THEREOF, ORGANIC COMPOSITIONS AND METAL SALTS CHEMEX PHARMACEUTICALS, INC. (US) 1988-06-02 WO claimed
WO-1987006833-A1 MODIFICATION OF PLANT EXTRACTS FROM ZYGOPHYLLACEAE CHEMEX PHARMACEUTICALS, INC. (US) 1987-11-19 WO claimed
US-4612190-A Growth inhibitor for cariogenic bacteria TAKASAGO PERFUMERY CO., LTD. (JP) 1986-09-16 US claimed