Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 6/20 | 1.00 |
| ▸ | ALOX12 | P18054 | 6/20 | 1.00 |
| ▸ | FOS | P01100 | 2/20 | 0.90 |
| ▸ | TTR | P02766 | 2/20 | 0.90 |
| ▸ | JUN | P05412 | 2/20 | 0.90 |
| ▸ | NR3C1 | P04150 | 2/20 | 0.90 |
| ▸ | HSD17B1 | P14061 | 2/20 | 0.90 |
| ▸ | HSD17B2 | P37059 | 2/20 | 0.90 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.73 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.73 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.73 |
| ▸ | MEN1 | O00255 | 2/20 | 0.73 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.73 |
| ▸ | ESR1 | P03372 | 2/20 | 0.73 |
| ▸ | TP53 | P04637 | 2/20 | 0.73 |
| ▸ | HPGD | P15428 | 2/20 | 0.73 |
| ▸ | RECQL | P46063 | 2/20 | 0.73 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.73 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.73 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.73 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29794171 | 1.00 | ALOX15 (1.00) | ALOX15ALOX12FOSTTRJUN | |
| SCHEMBL29929344 | 1.00 | ALOX15 (1.00) | ALOX15ALOX12FOSTTRJUN | |
| SCHEMBL4639890 | 1.00 | ALOX15 (1.00) | ALOX15ALOX12FOSTTRJUN | |
| Dihydroguaiaretic Acid SCHEMBL9087980 | 0.95 | FOS (1.00) | ALOX15ALOX12FOSTTRJUN | |
| Mesodihydroguaiaretic Acid SCHEMBL974725 | 0.95 | FOS (1.00) | ALOX15ALOX12FOSTTRJUN | |
| SCHEMBL22040032 | 0.92 | ALOX15 (1.00) | ALOX15ALOX12FOSTTRJUN | |
| SCHEMBL2390 | 0.90 | FOS (0.90) | ALOX15ALOX12FOSTTRJUN | |
| SCHEMBL16917560 | 0.90 | FOS (0.90) | ALOX15ALOX12FOSTTRJUN | |
| SCHEMBL3160 | 0.90 | ALOX15 (0.90) | ALOX15ALOX12FOSTTRJUN | |
| SCHEMBL31237435 | 0.90 | FOS (0.90) | ALOX15ALOX12FOSTTRJUN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8759394-B2 | 4-hydroxybutyric acid analogs | CONCERT PHARMACEUTICALS, INC. (US) | 2014-06-24 | — | — | US | disclosed |
| US-8420692-B1 | Heterocyclic and carbonate derivatives of NDGA and their use as new anti-HIV and anti-cancer agents | THE JOHNS HOPKINS UNIVERSITY (US) | 2013-04-16 | — | — | US | disclosed |
| US-8420692-B1 | Heterocyclic and carbonate derivatives of NDGA and their use as new anti-HIV and anti-cancer agents | THE JOHNS HOPKINS UNIVERSITY (US) | 2013-04-16 | — | — | US | disclosed |
| US-7741357-B1 | Heterocyclic and carbonate derivatives of NDGA and their use as new anti-HIV and anti-cancer agents | JOHNS HOPKINS UNIVERSITY (US) | 2010-06-22 | — | — | US | disclosed |
| US-7741357-B1 | Heterocyclic and carbonate derivatives of NDGA and their use as new anti-HIV and anti-cancer agents | JOHNS HOPKINS UNIVERSITY (US) | 2010-06-22 | — | — | US | disclosed |