Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RARB | P10826 | 14/20 | 1.00 |
| ▸ | RARG | P13631 | 13/20 | 1.00 |
| ▸ | RARA | P10276 | 12/20 | 1.00 |
| ▸ | RXRA | P19793 | 8/20 | 0.81 |
| ▸ | RXRB | P28702 | 7/20 | 0.81 |
| ▸ | RXRG | P48443 | 5/20 | 0.81 |
| ▸ | CYP26A1 | O43174 | 4/20 | 0.79 |
| ▸ | CYP26B1 | Q9NR63 | 4/20 | 0.79 |
| ▸ | MEN1 | O00255 | 1/20 | 0.57 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.57 |
| ▸ | ESR1 | P03372 | 1/20 | 0.57 |
| ▸ | PGR | P06401 | 1/20 | 0.57 |
| ▸ | HTR1A | P08908 | 1/20 | 0.57 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.57 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.57 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.57 |
| ▸ | DRD1 | P21728 | 1/20 | 0.57 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.57 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.57 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6818089 | 0.90 | RXRA (1.00) | RARBRARGRARARXRARXRB | |
| SCHEMBL7756675 | 0.89 | RARB (0.81) | RARBRARGRARARXRARXRB | |
| SCHEMBL2391376 | 0.88 | RARB (1.00) | RARBRARGRARARXRARXRB | |
| SCHEMBL29827631 | 0.86 | RARB (0.81) | RARBRARGRARARXRARXRB | |
| SCHEMBL846110 | 0.86 | RARB (0.81) | RARBRARGRARARXRARXRB | |
| SCHEMBL9746786 | 0.85 | RARB (0.74) | RARBRARGRARARXRARXRB | |
| Hydrochloric Acid SCHEMBL9120757 | 0.85 | RARB (0.78) | RARBRARGRARARXRARXRB | |
| SCHEMBL2331952 | 0.84 | RARB (1.00) | RARBRARGRARARXRARXRB | |
| SCHEMBL5712098 | 0.83 | RARB (0.75) | RARBRARGRARARXRARXRB | |
| SCHEMBL5712126 | 0.83 | RARB (0.75) | RARBRARGRARARXRARXRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0220118-B1 | BICYCLIC NAPHTHALENIC DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE IN HUMAN AND VETERINARY MEDICINE AND COSMETICS | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES GALDERMA - CIRD GALDERMA (FR) | 1992-01-02 | — | — | EP | claimed |
| US-7449495-B2 | Retinoid derivatives with antiangiogenic, antitumoral and proapoptotic activities | SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.P.A. (IT) | 2008-11-11 | — | — | US | disclosed |
| US-20080021088-A1 | Retinoid Derivatives With Antiangiogenic, Antitumoral And Proapoptotic Activities | SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.P.A. (IT) | 2008-01-24 | — | — | US | disclosed |
| US-4826969-A | SKIN AND EYE DISORDERS | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES C.I.R.D. (FR) | 1989-05-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080021088-A1 | Retinoid Derivatives With Antiangiogenic, Antitumoral And Proapoptotic Activities | RARA, RARB, RXRA | RARB 2/4885RARG 4/4885RARA 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.