Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RARB | P10826 | 17/20 | 0.80 |
| ▸ | RARG | P13631 | 17/20 | 0.80 |
| ▸ | RARA | P10276 | 16/20 | 0.80 |
| ▸ | CYP26A1 | O43174 | 4/20 | 0.71 |
| ▸ | CYP26B1 | Q9NR63 | 3/20 | 0.71 |
| ▸ | RXRA | P19793 | 4/20 | 0.62 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.59 |
| ▸ | NPC1 | O15118 | 1/20 | 0.59 |
| ▸ | GMNN | O75496 | 1/20 | 0.59 |
| ▸ | USP2 | O75604 | 1/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.59 |
| ▸ | LMNA | P02545 | 1/20 | 0.59 |
| ▸ | TP53 | P04637 | 1/20 | 0.59 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.59 |
| ▸ | POLB | P06746 | 1/20 | 0.59 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.59 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.59 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.59 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.59 |
| ▸ | THPO | P40225 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1615597 | 0.89 | RARB (1.00) | RARBRARGRARACYP26A1RXRA | |
| SCHEMBL1616018 | 0.89 | RARB (1.00) | RARBRARGRARACYP26A1RXRA | |
| SCHEMBL1615595 | 0.89 | RARB (1.00) | RARBRARGRARACYP26A1RXRA | |
| SCHEMBL9746789 | 0.86 | RARB (0.62) | RARBRARGRARACYP26A1CYP26B1 | |
| SCHEMBL5680238 | 0.83 | RXRA (0.81) | RARBRARGRARACYP26A1CYP26B1 | |
| SCHEMBL2391376 | 0.83 | RARB (1.00) | RARBRARGRARACYP26A1CYP26B1 | |
| SCHEMBL2331952 | 0.82 | RARB (1.00) | RARBRARGRARACYP26A1CYP26B1 | |
| SCHEMBL846110 | 0.81 | RARB (0.81) | RARBRARGRARACYP26A1CYP26B1 | |
| SCHEMBL29827631 | 0.81 | RARB (0.81) | RARBRARGRARACYP26A1CYP26B1 | |
| SCHEMBL9747842 | 0.81 | RARB (1.00) | RARBRARGRARACYP26A1CYP26B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0220118-B1 | BICYCLIC NAPHTHALENIC DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE IN HUMAN AND VETERINARY MEDICINE AND COSMETICS | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES GALDERMA - CIRD GALDERMA (FR) | 1992-01-02 | — | — | EP | claimed |
| US-4826969-A | SKIN AND EYE DISORDERS | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES C.I.R.D. (FR) | 1989-05-02 | — | — | US | disclosed |