Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA7 | P36544 | 3/20 | 0.53 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.51 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.51 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.51 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.51 |
| ▸ | HTR3A | P46098 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9531570 | 0.82 | CHRNA7 (0.52) | CHRNA7 | |
| SCHEMBL9531310 | 0.79 | CHRNA7 (0.51) | CHRNA7CHRNB2CHRNB4CHRNA3CHRNA4 | |
| Hydrochloric Acid SCHEMBL9531740 | 0.78 | CHRNA7 (0.50) | CHRNA7CHRNB2CHRNB4CHRNA3CHRNA4 | |
| SCHEMBL9748207 | 0.75 | HTR3A (0.53) | CHRNB2CHRNA3CHRNA4HTR3A | |
| SCHEMBL30117759 | 0.74 | CHRNA7 (0.53) | CHRNA7HTR3A | |
| SCHEMBL6412578 | 0.72 | CHRNA7 (0.64) | CHRNA7CHRNB2CHRNB4CHRNA3CHRNA4 | |
| SCHEMBL7447481 | 0.71 | HTR3A (0.56) | HTR3A | |
| SCHEMBL7447489 | 0.71 | HTR3A (0.56) | HTR3A | |
| Hydrochloric Acid SCHEMBL7438552 | 0.70 | HTR3A (0.55) | HTR3A | |
| SCHEMBL9556827 | 0.70 | CHRM2 (0.57) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0254584-B1 | AZABICYCLIC COMPOUNDS, PROCESS FOR THEIR PREPARATION, AND THEIR PHARMACEUTICAL USE | BEECHAM GROUP PLC (GB) | 1992-10-07 | — | — | EP | claimed |
| US-4822795-A | Pharmaceutically useful esters and amides | BEECHAM GROPUP P.L.C. (GB) | 1989-04-18 | — | — | US | claimed |
| EP-0254584-B1 | AZABICYCLIC COMPOUNDS, PROCESS FOR THEIR PREPARATION, AND THEIR PHARMACEUTICAL USE | BEECHAM GROUP PLC (GB) | 1992-10-07 | — | — | EP | disclosed |
| US-4822795-A | Pharmaceutically useful esters and amides | BEECHAM GROPUP P.L.C. (GB) | 1989-04-18 | — | — | US | disclosed |
| EP-0254584-A2 | Azabicyclic compounds, process for their preparation, and their pharmaceutical use | BEECHAM GROUP PLC (GB) | 1988-01-27 | — | — | EP | disclosed |