Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR4A2 | P43354 | 6/20 | 0.67 |
| ▸ | MAOB | P27338 | 1/20 | 0.63 |
| ▸ | GPR132 | Q9UNW8 | 2/20 | 0.62 |
| ▸ | SMPD1 | P17405 | 2/20 | 0.60 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.59 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.58 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.53 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9748476 | 0.92 | NR4A2 (0.62) | NR4A2MAOBGPR132SMPD1SRD5A2 | |
| SCHEMBL14490205 | 0.84 | MAOB (0.69) | NR4A2MAOBGPR132SMPD1SRD5A2 | |
| SCHEMBL3362951 | 0.83 | NR4A2 (0.70) | NR4A2MAOBGPR132SMPD1SRD5A2 | |
| SCHEMBL20364678 | 0.83 | MAOB (0.71) | NR4A2MAOBGPR132SMPD1SRD5A2 | |
| SCHEMBL5775340 | 0.82 | NR4A2 (0.65) | NR4A2MAOBGPR132SMPD1SRD5A2 | |
| SCHEMBL27576886 | 0.82 | MAOB (0.61) | NR4A2MAOBGPR132SMPD1SRD5A2 | |
| SCHEMBL9748714 | 0.81 | MDM2 (0.50) | MEN1KMT2AALDH1A1 | |
| SCHEMBL11033672 | 0.81 | MAOB (0.68) | NR4A2MAOBGPR132SMPD1SRD5A2 | |
| SCHEMBL339009 | 0.81 | NR4A2 (1.00) | NR4A2MAOBSMPD1SRD5A2PTPN1 | |
| SCHEMBL30207018 | 0.81 | NR4A2 (1.00) | NR4A2MAOBSMPD1SRD5A2PTPN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5120874-A | Process for the preparation of 5-hydroxydiprafenone and its acid addition salts | HELOPHARM W. PETRIK GMBH & CO. KG (DE) | 1992-06-09 | — | — | US | claimed |
| EP-0283540-B1 | PROCESS FOR THE PREPARATION OF 5-HYDROXYDIPRAPHENONE AND ITS SALTS WITH ACIDS | Helopharm W. Petrik GmbH & Co.KG. (DE) | 1991-09-18 | — | — | EP | claimed |
| US-5120874-A | Process for the preparation of 5-hydroxydiprafenone and its acid addition salts | HELOPHARM W. PETRIK GMBH & CO. KG (DE) | 1992-06-09 | — | — | US | disclosed |