Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MDM2 | Q00987 | 1/20 | 0.50 |
| ▸ | CA12 | O43570 | 1/20 | 0.50 |
| ▸ | CA1 | P00915 | 1/20 | 0.50 |
| ▸ | CA2 | P00918 | 1/20 | 0.50 |
| ▸ | CA6 | P23280 | 1/20 | 0.50 |
| ▸ | CA9 | Q16790 | 1/20 | 0.50 |
| ▸ | HPGDS | O60760 | 3/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | PARP1 | P09874 | 1/20 | 0.44 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.43 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.42 |
| ▸ | NOS2 | P35228 | 1/20 | 0.42 |
| ▸ | CTRB1 | P17538 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9748709 | 0.90 | MDM2 (0.50) | MDM2CA12CA1CA2CA6 | |
| SCHEMBL26065 | 0.84 | MDM2 (0.68) | MDM2ALDH1A1CTRB1CYP1A2MAPT | |
| SCHEMBL10830284 | 0.83 | MDM2 (0.49) | MDM2KDM4EALDH1A1PARP1MEN1 | |
| SCHEMBL9748480 | 0.81 | NR4A2 (0.67) | ALDH1A1MEN1KMT2A | |
| SCHEMBL2976486 | 0.80 | CA12 (0.52) | CA12CA1CA2CA6CA9 | |
| SCHEMBL11093598 | 0.78 | CA12 (0.50) | CA12CA1CA2CA6CA9 | |
| Hydrochloric Acid SCHEMBL7788543 | 0.78 | HPGDS (0.52) | MDM2CA12CA1CA2CA6 | |
| SCHEMBL28565188 | 0.77 | CA12 (0.50) | CA12CA1CA2CA6CA9 | |
| SCHEMBL7162983 | 0.77 | NPC1 (0.55) | MDM2CA12CA1CA2CA6 | |
| SCHEMBL7114759 | 0.77 | NPC1 (0.55) | MDM2CA12CA1CA2CA6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5120874-A | Process for the preparation of 5-hydroxydiprafenone and its acid addition salts | HELOPHARM W. PETRIK GMBH & CO. KG (DE) | 1992-06-09 | — | — | US | claimed |
| EP-0283540-B1 | PROCESS FOR THE PREPARATION OF 5-HYDROXYDIPRAPHENONE AND ITS SALTS WITH ACIDS | Helopharm W. Petrik GmbH & Co.KG. (DE) | 1991-09-18 | — | — | EP | claimed |
| US-5120874-A | Process for the preparation of 5-hydroxydiprafenone and its acid addition salts | HELOPHARM W. PETRIK GMBH & CO. KG (DE) | 1992-06-09 | — | — | US | disclosed |