Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 9/20 | 0.38 |
| ▸ | PIM2 | Q9P1W9 | 4/20 | 0.38 |
| ▸ | GSK3A | P49840 | 2/20 | 0.38 |
| ▸ | PIM3 | Q86V86 | 2/20 | 0.38 |
| ▸ | TOP1 | P11387 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 3/20 | 0.32 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.32 |
| ▸ | DRD3 | P35462 | 1/20 | 0.32 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.32 |
| ▸ | GSK3B | P49841 | 1/20 | 0.32 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.32 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.32 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.32 |
| ▸ | CSNK1G3 | Q9Y6M4 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10553019 | 0.85 | PIM1 (0.35) | PIM1PIM2GSK3APIM3KDM4E | |
| SCHEMBL9341876 | 0.83 | PIM1 (0.50) | PIM1PIM2GSK3APIM3KDM4E | |
| SCHEMBL20527932 | 0.81 | PIM1 (0.48) | PIM1PIM2GSK3APIM3KDM4E | |
| SCHEMBL9715578 | 0.79 | KDM4E (0.39) | PIM1PIM2GSK3APIM3KDM4E | |
| SCHEMBL10427396 | 0.78 | CCR3 (0.37) | PIM1PIM2GSK3APIM3KDM4E | |
| SCHEMBL9748573 | 0.77 | PIM1 (0.36) | PIM1PIM2GSK3APIM3HPGD | |
| SCHEMBL10744402 | 0.71 | PIM1 (0.37) | PIM1PIM2GSK3APIM3KDM4E | |
| SCHEMBL10751688 | 0.71 | PIM1 (0.38) | PIM1PIM2GSK3APIM3LMNA | |
| SCHEMBL6212035 | 0.70 | TOP1 (0.41) | PIM1TOP1KDM4EMAPTHPGD | |
| SCHEMBL6714654 | 0.70 | IDO1 (0.39) | PIM1PIM2GSK3APIM3KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0248072-B1 | AMIFLOXACINE INTERMEDIATE | CHINOIN Gyogyszer és Vegyészeti Termékek Gyára RT. (HU) | 1992-03-18 | — | — | EP | disclosed |
| US-4806645-A | Boric anhydrides of 6-fluoro-7-chloro-1-methylamino-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid | CHINOIN GYOGYSZER ES VEGYESZETI TERMEKEK GYARA RT. (HU) | 1989-02-21 | — | — | US | disclosed |
| EP-0248072-A1 | AMIFLOXACINE INTERMEDIATE. | CHINOIN GYOGYSZER ES VEGYESZET (HU) | 1987-12-09 | — | — | EP | disclosed |
| WO-1987003594-A1 | AMIFLOXACINE INTERMEDIATE | CHINOIN GYÓGYSZERRÉS VEGYÉSZETI TERMÉKEK GYÁRA RT. (HU) | 1987-06-18 | — | — | WO | disclosed |