Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACKR3 | P25106 | 2/20 | 0.61 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.57 |
| ▸ | DRD4 | P21917 | 7/20 | 0.56 |
| ▸ | MCHR1 | Q99705 | 6/20 | 0.53 |
| ▸ | SLC6A12 | P48065 | 1/20 | 0.53 |
| ▸ | SLC6A13 | Q9NSD5 | 1/20 | 0.53 |
| ▸ | CCR3 | P51677 | 2/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9748562 | 0.96 | DRD4 (0.61) | ACKR3DRD4MCHR1SLC6A12SLC6A13 | |
| SCHEMBL9589358 | 0.93 | DRD4 (0.67) | ACKR3CXCR4DRD4MCHR1SLC6A12 | |
| SCHEMBL9748813 | 0.93 | CCR3 (0.62) | ACKR3DRD4MCHR1CCR3 | |
| SCHEMBL9592513 | 0.91 | CXCR4 (0.61) | ACKR3CXCR4DRD4MCHR1CCR3 | |
| SCHEMBL9748969 | 0.85 | ACKR3 (0.52) | ACKR3CXCR4DRD4MCHR1SLC6A12 | |
| SCHEMBL9750306 | 0.80 | PLK1 (0.56) | ACKR3SMN1; SMN2 | |
| SCHEMBL9592427 | 0.80 | MCHR1 (0.70) | DRD4MCHR1SLC6A12SLC6A13CCR3 | |
| SCHEMBL9592834 | 0.80 | DRD4 (0.67) | CXCR4DRD4MCHR1SLC6A12SLC6A13 | |
| Panuramine SCHEMBL2037759 | 0.79 | MCHR1 (0.83) | DRD4MCHR1SLC6A12SLC6A13CCR3 | |
| SCHEMBL9591749 | 0.79 | MCHR1 (0.62) | DRD4MCHR1SLC6A12SLC6A13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0234098-B1 | N-[piperidylaminocarbonyl]quinolinecarboxamide derivatives having psychotropic activity | JOHN WYETH & BROTHER LIMITED (GB) | 1992-02-26 | — | — | EP | claimed |
| US-4778802-A | PSYCHOTROPIC ACTIVITY; ANTIDEPRESSANTS | JOHN WYETH & BROTHER, LTD. (GB) | 1988-10-18 | — | — | US | claimed |
| EP-0234098-A1 | N-[piperidylaminocarbonyl]quinolinecarboxamide derivatives having psychotropic activity | JOHN WYETH & BROTHER LIMITED (GB) | 1987-09-02 | — | — | EP | claimed |
| EP-0234098-B1 | N-[piperidylaminocarbonyl]quinolinecarboxamide derivatives having psychotropic activity | JOHN WYETH & BROTHER LIMITED (GB) | 1992-02-26 | — | — | EP | disclosed |
| US-4778802-A | PSYCHOTROPIC ACTIVITY; ANTIDEPRESSANTS | JOHN WYETH & BROTHER, LTD. (GB) | 1988-10-18 | — | — | US | disclosed |
| EP-0234098-A1 | N-[piperidylaminocarbonyl]quinolinecarboxamide derivatives having psychotropic activity | JOHN WYETH & BROTHER LIMITED (GB) | 1987-09-02 | — | — | EP | disclosed |