Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACKR3 | P25106 | 2/20 | 0.52 |
| ▸ | DRD4 | P21917 | 6/20 | 0.49 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.48 |
| ▸ | HTR3A | P46098 | 1/20 | 0.46 |
| ▸ | CCR3 | P51677 | 4/20 | 0.45 |
| ▸ | PLK1 | P53350 | 1/20 | 0.44 |
| ▸ | SLC6A12 | P48065 | 1/20 | 0.44 |
| ▸ | SLC6A13 | Q9NSD5 | 1/20 | 0.44 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.44 |
| ▸ | DRD2 | P14416 | 2/20 | 0.43 |
| ▸ | HTR2A | P28223 | 2/20 | 0.43 |
| ▸ | DRD3 | P35462 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9748761 | 0.85 | ACKR3 (0.61) | ACKR3DRD4CXCR4CCR3SLC6A12 | |
| SCHEMBL9748562 | 0.82 | DRD4 (0.61) | ACKR3DRD4SLC6A12SLC6A13MCHR1 | |
| SCHEMBL9748813 | 0.79 | CCR3 (0.62) | ACKR3DRD4CCR3MCHR1 | |
| SCHEMBL9589358 | 0.79 | DRD4 (0.67) | ACKR3DRD4CXCR4CCR3SLC6A12 | |
| SCHEMBL9592513 | 0.77 | CXCR4 (0.61) | ACKR3DRD4CXCR4CCR3MCHR1 | |
| SCHEMBL9750306 | 0.76 | PLK1 (0.56) | ACKR3HTR3APLK1 | |
| SCHEMBL9591604 | 0.71 | DRD4 (0.65) | DRD4SLC6A12MCHR1DRD2DRD3 | |
| SCHEMBL9591681 | 0.70 | DRD4 (0.61) | ACKR3DRD4CCR3MCHR1DRD2 | |
| SCHEMBL10530618 | 0.69 | ADRA2A (0.69) | DRD4CXCR4HTR3ADRD2HTR2A | |
| SCHEMBL17270267 | 0.68 | ACKR3 (1.00) | ACKR3CCR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0234098-B1 | N-[piperidylaminocarbonyl]quinolinecarboxamide derivatives having psychotropic activity | JOHN WYETH & BROTHER LIMITED (GB) | 1992-02-26 | — | — | EP | claimed |