Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNE1 | P15382 | 10/20 | 0.49 |
| ▸ | KCNQ1 | P51787 | 10/20 | 0.49 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.49 |
| ▸ | PPARA | Q07869 | 3/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.38 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | BACE1 | P56817 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | PPARG | P37231 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9032517 | 0.83 | KCNE1 (0.42) | KCNE1KCNQ1KCNH2BACE1 | |
| SCHEMBL8803927 | 0.83 | KCNE1 (0.42) | KCNE1KCNQ1KCNH2BACE1 | |
| SCHEMBL8803932 | 0.83 | KCNE1 (0.42) | KCNE1KCNQ1KCNH2BACE1 | |
| SCHEMBL9529241 | 0.80 | HTR2B (0.43) | KCNE1KCNQ1KCNH2 | |
| SCHEMBL9529232 | 0.80 | HTR2B (0.43) | KCNE1KCNQ1KCNH2 | |
| SCHEMBL9529220 | 0.80 | HTR2B (0.43) | KCNE1KCNQ1KCNH2 | |
| SCHEMBL9270605 | 0.79 | PNMT (0.39) | KCNE1KCNQ1KCNH2BACE1CYP1A2 | |
| SCHEMBL9270612 | 0.79 | PNMT (0.39) | KCNE1KCNQ1KCNH2BACE1CYP1A2 | |
| SCHEMBL9270610 | 0.79 | PNMT (0.39) | KCNE1KCNQ1KCNH2BACE1CYP1A2 | |
| SCHEMBL9741201 | 0.74 | ABCC9 (0.61) | KCNE1KCNQ1KCNH2PPARACYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1992012153-A1 | NOVEL ANTIHYPERTENSIVE BENZOPYRAN DERIVATIVES | AMERICAN HOME PRODUCTS CORPORATION (US) | 1992-07-23 | — | — | WO | disclosed |