Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.51 |
| ▸ | HPGD | P15428 | 4/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.51 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.50 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.47 |
| ▸ | TOP2A | P11388 | 3/20 | 0.43 |
| ▸ | TOP2B | Q02880 | 3/20 | 0.43 |
| ▸ | TOP1 | P11387 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.42 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.42 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.42 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.42 |
| ▸ | ALB | P02768 | 1/20 | 0.42 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.42 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9749012 | 0.91 | KDM4E (0.61) | KDM4EALDH1A1HPGDHSD17B10PMP22 | |
| SCHEMBL9837564 | 0.85 | KDM4E (0.62) | KDM4EALDH1A1HPGDHSD17B10PMP22 | |
| SCHEMBL10425078 | 0.82 | KDM4E (0.64) | KDM4EALDH1A1HPGDHSD17B10PMP22 | |
| SCHEMBL10425075 | 0.82 | KDM4E (0.64) | KDM4EALDH1A1HPGDHSD17B10PMP22 | |
| SCHEMBL9837322 | 0.81 | KDM4E (0.60) | KDM4EALDH1A1HPGDHSD17B10PMP22 | |
| SCHEMBL9749400 | 0.81 | ALDH1A1 (0.65) | KDM4EALDH1A1HPGDHSD17B10TOP2A | |
| SCHEMBL9749475 | 0.81 | KDM4E (0.71) | KDM4EALDH1A1HPGDHSD17B10PMP22 | |
| SCHEMBL10425073 | 0.80 | KDM4E (0.70) | KDM4EALDH1A1HPGDHSD17B10PMP22 | |
| Fleroxacin SCHEMBL29377022 | 0.80 | KDM4E (1.00) | KDM4EALDH1A1HPGDHSD17B10PMP22 | |
| Fleroxacin SCHEMBL48145 | 0.80 | KDM4E (1.00) | KDM4EALDH1A1HPGDHSD17B10PMP22 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5091383-A | SUBSTITUTED BRIDGED DIAZABICYCLOALKYL QUINOLONE CARBOXYLIC ACIDS | PFIZER INC. (US) | 1992-02-25 | — | — | US | disclosed |
| EP-0215650-B1 | SUBSTITUTED BRIDGED-DIAZABICYCLOALKYL QUINOLONE CARBOXYLIC ACIDS | PFIZER INC. (US) | 1992-01-29 | — | — | EP | disclosed |
| US-4861779-A | Anti-bacterial substituted bridged-diazabicycloalkyl quinolone carboxylic acids | PFIZER INC. (US) | 1989-08-29 | — | — | US | disclosed |
| US-4775668-A | Substituted bridged-diazabicycloalkyl quinolone carboxylic acids and anti-bacterial use thereof | PFIZER INC. (US) | 1988-10-04 | — | — | US | disclosed |
| EP-0215650-A2 | Substituted bridged-diazabicycloalkyl quinolone carboxylic acids | PFIZER INC. (US) | 1987-03-25 | — | — | EP | disclosed |