Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.35 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | GBA1 | P04062 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9749643 | 0.79 | APEX1 (0.40) | TSHRALDH1A1HSD17B10LMNASMN1; SMN2 | |
| SCHEMBL9749161 | 0.78 | APEX1 (0.39) | TSHRMEN1KMT2AALDH1A1HSD17B10 | |
| SCHEMBL9748936 | 0.77 | APEX1 (0.51) | TSHRALDH1A1HSD17B10HTTSMN1; SMN2 | |
| SCHEMBL13471446 | 0.75 | MAPT (0.42) | TSHRMEN1KMT2ARAB9AALDH1A1 | |
| SCHEMBL9750212 | 0.74 | KMT2A (0.43) | TSHRMEN1KMT2ARAB9AALDH1A1 | |
| SCHEMBL13471235 | 0.74 | TSHR (0.56) | TSHRMEN1KMT2ARAB9AALDH1A1 | |
| SCHEMBL10690648 | 0.70 | TSHR (0.41) | TSHRMEN1KMT2ARAB9AALDH1A1 | |
| SCHEMBL9749308 | 0.67 | ALDH1A1 (0.32) | ALDH1A1HSD17B10L3MBTL1 | |
| SCHEMBL9749305 | 0.67 | ALDH1A1 (0.32) | ALDH1A1HSD17B10L3MBTL1 | |
| SCHEMBL10685537 | 0.66 | TSHR (0.39) | TSHRRAB9AALDH1A1MAPTHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0194572-B1 | HETEROCYCLIC SULFIDES, PROCESS FOR THEIR PREPARATION AND MEDICAMENTS CONTAINING THEM | HOECHST AKTIENGESELLSCHAFT (DE) | 1992-01-02 | — | — | EP | disclosed |
| EP-0194572-A1 | Heterocyclic sulfides, process for their preparation and Medicaments containing them | HOECHST AKTIENGESELLSCHAFT (DE) | 1986-09-17 | — | — | EP | disclosed |