Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP2A | P11388 | 13/20 | 0.37 |
| ▸ | TOP2B | Q02880 | 10/20 | 0.37 |
| ▸ | AADAT | Q8N5Z0 | 2/20 | 0.37 |
| ▸ | TOP1 | P11387 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.35 |
| ▸ | ALB | P02768 | 1/20 | 0.35 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.35 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | TUBB | P07437 | 1/20 | 0.35 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.35 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.35 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.35 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.35 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.35 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.35 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10426106 | 0.90 | TOP2A (0.47) | TOP2ATOP2BAADATTOP1KDM4E | |
| SCHEMBL9749905 | 0.85 | ALDH1A1 (0.44) | TOP2ATOP2BAADATKDM4EALDH1A1 | |
| SCHEMBL9749829 | 0.85 | AADAT (0.39) | TOP2ATOP2BAADATTOP1KDM4E | |
| SCHEMBL9750063 | 0.84 | KDM4E (0.39) | TOP2ATOP2BAADATTOP1KDM4E | |
| SCHEMBL9749812 | 0.84 | AADAT (0.39) | TOP2ATOP2BAADATTOP1KDM4E | |
| SCHEMBL10424572 | 0.76 | ALDH1A1 (0.57) | TOP2ATOP2BAADATKDM4EALDH1A1 | |
| SCHEMBL9212047 | 0.76 | TOP1 (0.39) | TOP2ATOP2BTOP1KDM4EALDH1A1 | |
| SCHEMBL10914849 | 0.75 | TOP1 (0.53) | TOP2ATOP2BTOP1ALDH1A1POLB | |
| SCHEMBL10424658 | 0.74 | KDM4E (0.51) | TOP2ATOP2BAADATTOP1KDM4E | |
| SCHEMBL9749825 | 0.74 | AADAT (0.48) | TOP2ATOP2BAADATTOP1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0216345-B1 | QUINOLINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 1992-02-19 | — | — | EP | disclosed |
| EP-0216345-A2 | Quinoline derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 1987-04-01 | — | — | EP | disclosed |