Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.39 |
| ▸ | HPGD | P15428 | 4/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.39 |
| ▸ | AADAT | Q8N5Z0 | 2/20 | 0.39 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.39 |
| ▸ | ALB | P02768 | 1/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.37 |
| ▸ | TUBB | P07437 | 1/20 | 0.37 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.37 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.37 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.37 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.37 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.37 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.37 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.37 |
| ▸ | TUBA3E | Q6PEY2 | 1/20 | 0.37 |
| ▸ | TUBA1A | Q71U36 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10424658 | 0.89 | KDM4E (0.51) | KDM4EALDH1A1HPGDHSD17B10AADAT | |
| SCHEMBL9749812 | 0.86 | AADAT (0.39) | KDM4EALDH1A1HPGDHSD17B10AADAT | |
| SCHEMBL9749905 | 0.86 | ALDH1A1 (0.44) | KDM4EALDH1A1HPGDHSD17B10AADAT | |
| SCHEMBL9749876 | 0.84 | TOP2A (0.37) | KDM4EALDH1A1HPGDHSD17B10AADAT | |
| SCHEMBL9837418 | 0.79 | ALDH1A1 (0.44) | KDM4EALDH1A1HPGDHSD17B10PMP22 | |
| SCHEMBL10424505 | 0.77 | AADAT (0.48) | KDM4EALDH1A1HPGDHSD17B10AADAT | |
| SCHEMBL10424572 | 0.76 | ALDH1A1 (0.57) | KDM4EALDH1A1HPGDHSD17B10AADAT | |
| SCHEMBL9838758 | 0.76 | KDM4E (0.48) | KDM4EALDH1A1HPGDHSD17B10PMP22 | |
| SCHEMBL9839393 | 0.76 | KDM4E (0.46) | KDM4EALDH1A1HPGDHSD17B10PMP22 | |
| SCHEMBL9838559 | 0.76 | KDM4E (0.49) | KDM4EALDH1A1HPGDHSD17B10PMP22 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0216345-B1 | QUINOLINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 1992-02-19 | — | — | EP | disclosed |
| EP-0216345-A2 | Quinoline derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 1987-04-01 | — | — | EP | disclosed |