Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.43 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.42 |
| ▸ | MAOB | P27338 | 6/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.40 |
| ▸ | FSHR | P23945 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | MAOA | P21397 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.39 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.39 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.39 |
| ▸ | BCHE | P06276 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9750432 | 0.85 | HRH3 (0.48) | HRH3ALOX5MAOBMEN1NPC1 | |
| SCHEMBL4615673 | 0.80 | ALDH1A1 (0.45) | MEN1KMT2AKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL11019035 | 0.77 | HRH3 (0.48) | HRH3ALOX5MAOBMEN1NPC1 | |
| SCHEMBL9893372 | 0.76 | KCNA5 (0.50) | ALOX5MAOBTP53MAOASIRT2 | |
| SCHEMBL28250868 | 0.74 | POLB (0.48) | HRH3ALOX5MAOBMEN1NPC1 | |
| SCHEMBL9750274 | 0.73 | MAOB (0.43) | HRH3MAOBNPC1SMN1; SMN2RAB9A | |
| SCHEMBL6091601 | 0.73 | KMT2A (0.46) | MEN1NPC1KMT2ATP53KDM4E | |
| SCHEMBL9750098 | 0.72 | MAOB (0.46) | MAOBMEN1KMT2AMAOA | |
| SCHEMBL9893431 | 0.72 | KCNA5 (0.58) | — | |
| SCHEMBL9893318 | 0.72 | KCNA5 (0.45) | HRH3MAOBTP53MAOASIRT2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5120858-A | Condensation of 2-methyleneindoline and formic acid in acetic anhydride | MILES INC. (US) | 1992-06-09 | — | — | US | disclosed |
| EP-0058863-B1 | PROCESS FOR THE PREPARATION OF TRIMETHINE DYESTUFFS | BAYER AG (DE) | 1985-01-23 | — | — | EP | disclosed |
| US-4419511-A | Process for the preparation of trimethine dyestuffs | BAYER AKTIENGESELLSCHAFT (US) | 1983-12-06 | — | — | US | disclosed |
| EP-0058863-A1 | Process for the preparation of trimethine dyestuffs | BAYER AG (DE) | 1982-09-01 | — | — | EP | disclosed |