Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.72 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.72 |
| ▸ | HPGD | P15428 | 5/20 | 0.72 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.72 |
| ▸ | HTT | P42858 | 4/20 | 0.72 |
| ▸ | LMNA | P02545 | 3/20 | 0.72 |
| ▸ | TSHR | P16473 | 2/20 | 0.72 |
| ▸ | BRD4 | O60885 | 1/20 | 0.72 |
| ▸ | CYP2J2 | P51589 | 1/20 | 0.72 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.72 |
| ▸ | DRD3 | P35462 | 1/20 | 0.67 |
| ▸ | MEN1 | O00255 | 5/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.62 |
| ▸ | NPC1 | O15118 | 1/20 | 0.62 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.58 |
| ▸ | USP2 | O75604 | 1/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.57 |
| ▸ | MAPT | P10636 | 1/20 | 0.55 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.55 |
| ▸ | PIK3R1 | P27986 | 2/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9749226 | 0.94 | KDM4E (0.71) | KDM4EALDH1A1HPGDHSD17B10HTT | |
| SCHEMBL9048236 | 0.86 | TOP1 (0.71) | KDM4EALDH1A1HPGDHSD17B10HTT | |
| Hydrochloric Acid SCHEMBL8571733 | 0.85 | TOP1 (0.70) | KDM4EALDH1A1HPGDHSD17B10HTT | |
| SCHEMBL10621421 | 0.85 | TOP1 (0.72) | KDM4EALDH1A1HPGDHSD17B10HTT | |
| Norfloxacin SCHEMBL27395494 | 0.84 | ALDH1A1 (1.00) | KDM4EALDH1A1HPGDHSD17B10HTT | |
| Norfloxacin SCHEMBL2221304 | 0.84 | ALDH1A1 (1.00) | KDM4EALDH1A1HPGDHSD17B10HTT | |
| Norfloxacin SCHEMBL3473 | 0.84 | ALDH1A1 (1.00) | KDM4EALDH1A1HPGDHSD17B10HTT | |
| SCHEMBL9749182 | 0.84 | DRD3 (0.69) | KDM4EALDH1A1HPGDHSD17B10HTT | |
| SCHEMBL10619341 | 0.84 | DRD3 (0.66) | KDM4EALDH1A1HPGDHSD17B10HTT | |
| SCHEMBL5752305 | 0.83 | KDM4E (0.76) | KDM4EALDH1A1HPGDHSD17B10HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5091383-A | SUBSTITUTED BRIDGED DIAZABICYCLOALKYL QUINOLONE CARBOXYLIC ACIDS | PFIZER INC. (US) | 1992-02-25 | — | — | US | disclosed |
| EP-0215650-B1 | SUBSTITUTED BRIDGED-DIAZABICYCLOALKYL QUINOLONE CARBOXYLIC ACIDS | PFIZER INC. (US) | 1992-01-29 | — | — | EP | disclosed |
| US-4861779-A | Anti-bacterial substituted bridged-diazabicycloalkyl quinolone carboxylic acids | PFIZER INC. (US) | 1989-08-29 | — | — | US | disclosed |
| US-4775668-A | Substituted bridged-diazabicycloalkyl quinolone carboxylic acids and anti-bacterial use thereof | PFIZER INC. (US) | 1988-10-04 | — | — | US | disclosed |
| EP-0215650-A2 | Substituted bridged-diazabicycloalkyl quinolone carboxylic acids | PFIZER INC. (US) | 1987-03-25 | — | — | EP | disclosed |