Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.46 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.46 |
| ▸ | PIM1 | P11309 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 5/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.45 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.43 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.41 |
| ▸ | CLK2 | P49760 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | TOP2A | P11388 | 3/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9749281 | 0.84 | LMNA (0.50) | KDM4EALDH1A1POLBHSP90AA1RXFP1 | |
| SCHEMBL9378328 | 0.83 | KCNH2 (0.55) | KDM4EALDH1A1POLBLMNAMEN1 | |
| SCHEMBL9129939 | 0.83 | KDM4E (0.61) | KDM4EALDH1A1POLBHSP90AA1RXFP1 | |
| SCHEMBL9748406 | 0.83 | KDM4E (0.61) | KDM4EALDH1A1POLBHSP90AA1RXFP1 | |
| SCHEMBL9837602 | 0.82 | HSD17B10 (0.64) | KDM4EALDH1A1POLBPIM1LMNA | |
| SCHEMBL10391017 | 0.82 | KDM4E (0.45) | KDM4EALDH1A1POLBLMNAMEN1 | |
| SCHEMBL9146453 | 0.80 | PIM1 (0.49) | KDM4EALDH1A1POLBHSP90AA1RXFP1 | |
| SCHEMBL9146460 | 0.80 | PIM1 (0.49) | KDM4EALDH1A1POLBHSP90AA1RXFP1 | |
| SCHEMBL9146445 | 0.80 | PIM1 (0.49) | KDM4EALDH1A1POLBHSP90AA1RXFP1 | |
| SCHEMBL9661718 | 0.80 | EPHA2 (0.43) | KDM4EALDH1A1POLBLMNAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5091383-A | SUBSTITUTED BRIDGED DIAZABICYCLOALKYL QUINOLONE CARBOXYLIC ACIDS | PFIZER INC. (US) | 1992-02-25 | — | — | US | disclosed |