Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.42 |
| ▸ | HPGD | P15428 | 5/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.42 |
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | FPR2 | P25090 | 1/20 | 0.40 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.40 |
| ▸ | PIM1 | P11309 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.35 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | TOP2A | P11388 | 4/20 | 0.35 |
| ▸ | TOP2B | Q02880 | 3/20 | 0.35 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.35 |
| ▸ | TOP1 | P11387 | 3/20 | 0.34 |
| ▸ | BRD4 | O60885 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9750401 | 0.90 | KDM4E (0.53) | KDM4EALDH1A1HPGDHSD17B10LMNA | |
| SCHEMBL9749299 | 0.87 | KDM4E (0.40) | KDM4EALDH1A1HPGDHSD17B10LMNA | |
| SCHEMBL9749310 | 0.86 | LMNA (0.41) | KDM4EALDH1A1HPGDHSD17B10LMNA | |
| SCHEMBL10914301 | 0.85 | KDM4E (0.52) | KDM4EALDH1A1HPGDHSD17B10LMNA | |
| SCHEMBL9749842 | 0.85 | KCNH2 (0.42) | KDM4EALDH1A1HPGDHSD17B10LMNA | |
| SCHEMBL9750395 | 0.85 | KDM4E (0.36) | KDM4EALDH1A1HPGDHSD17B10LMNA | |
| SCHEMBL10915561 | 0.79 | HPGD (0.51) | KDM4EALDH1A1HPGDHSD17B10LMNA | |
| SCHEMBL10915439 | 0.79 | HPGD (0.47) | KDM4EALDH1A1HPGDHSD17B10LMNA | |
| SCHEMBL10649327 | 0.78 | KDM4E (0.39) | KDM4EALDH1A1HPGDHSD17B10LMNA | |
| SCHEMBL10914020 | 0.78 | KDM4E (0.57) | KDM4EALDH1A1HPGDHSD17B10LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0216345-B1 | QUINOLINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 1992-02-19 | — | — | EP | disclosed |
| EP-0216345-A2 | Quinoline derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 1987-04-01 | — | — | EP | disclosed |