Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 9/20 | 0.49 |
| ▸ | TRPM8 | Q7Z2W7 | 3/20 | 0.49 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.46 |
| ▸ | HTR2C | P28335 | 3/20 | 0.45 |
| ▸ | HTR6 | P50406 | 3/20 | 0.43 |
| ▸ | HTR1D | P28221 | 3/20 | 0.42 |
| ▸ | MPO | P05164 | 2/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.42 |
| ▸ | HTR1B | P28222 | 2/20 | 0.42 |
| ▸ | HTR7 | P34969 | 2/20 | 0.42 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.42 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.42 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.42 |
| ▸ | CTSK | P43235 | 1/20 | 0.42 |
| ▸ | CYP2A13 | Q16696 | 1/20 | 0.42 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22803795 | 0.79 | HTR2A (0.61) | HTR2ATRPM8HTR2CHTR6HTR1D | |
| SCHEMBL8114974 | 0.79 | CHEK1 (0.43) | CHEK1HTR6CYP2A6AHRCHRNB2 | |
| SCHEMBL9749879 | 0.76 | HTR6 (0.39) | CHEK1HTR6CYP1A2CYP3A4CYP2A6 | |
| SCHEMBL2533934 | 0.76 | HTR2A (0.76) | HTR2ATRPM8HTR2CHTR6HTR1D | |
| SCHEMBL32684044 | 0.76 | HTR2A (0.76) | HTR2ATRPM8HTR2CHTR6HTR1D | |
| Hydrochloric Acid SCHEMBL2706928 | 0.75 | HTR2A (0.73) | HTR2ATRPM8HTR2CHTR6HTR1D | |
| SCHEMBL27973185 | 0.73 | ALDH1A1 (0.42) | HTR6NFKB1PMP22MEN1KMT2A | |
| SCHEMBL30776660 | 0.73 | HTR2A (0.59) | HTR2ATRPM8HTR2CHTR6HTR1D | |
| SCHEMBL2239944 | 0.73 | HTR2A (0.59) | HTR2ATRPM8HTR2CHTR6HTR1D | |
| Cyanide SCHEMBL29233342 | 0.72 | HTR2A (0.69) | HTR2ATRPM8HTR2CHTR6HTR1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0266349-B1 | TRICYCLIC INDOLE DERIVATIVES, THEIR MANUFACTURE AND USE AS MEDICINES | SCHERING AKTIENGESELLSCHAFT (DE) | 1992-03-18 | — | — | EP | disclosed |
| EP-0266349-A1 | TRICYCLIC INDOLE DERIVATIVES, THEIR MANUFACTURE AND USE AS MEDICINES. | SCHERING AG (DE) | 1988-05-11 | — | — | EP | disclosed |
| WO-1987000522-A1 | TRICYCLIC INDOLE DERIVATIVES, THEIR MANUFACTURE AND USE AS MEDICINES | SCHERING AKTIENGESELLSCHAFT BERLIN UND BERGKAMEN (DE) | 1987-01-29 | — | — | WO | disclosed |