SCHEMBL9751747

SCHEMBL9751747

CCOc1ccc(-c2ccc(F)c(F)c2)cc1

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NQO1 P15559 1/20 0.54
CHRNA7 P36544 3/20 0.50
FFAR1 O14842 2/20 0.48
FFAR4 Q5NUL3 2/20 0.48
CYP11B1 P15538 2/20 0.46
CYP11B2 P19099 2/20 0.46
TSHR P16473 1/20 0.45
TDP1 Q9NUW8 1/20 0.45
ALDH1A1 P00352 2/20 0.45
RARA P10276 1/20 0.44
RARB P10826 1/20 0.44
KDM4E B2RXH2 1/20 0.44
NPC1 O15118 1/20 0.44
LMNA P02545 1/20 0.44
RAB9A P51151 1/20 0.44
XDH P47989 1/20 0.44
POLB P06746 1/20 0.43
L3MBTL1 Q9Y468 1/20 0.43
CYP17A1 P05093 1/20 0.43
PPARD Q03181 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1547853 0.84 NQO1 (0.56) NQO1CHRNA7FFAR1FFAR4TSHR
SCHEMBL8767150 0.82 CHRNA7 (0.41) NQO1CHRNA7FFAR1FFAR4CYP11B1
SCHEMBL18310399 0.81 FFAR1 (0.50) NQO1FFAR1FFAR4CYP11B1CYP11B2
SCHEMBL9155582 0.81 NQO1 (0.82) NQO1TSHRTDP1ALDH1A1KDM4E
SCHEMBL5833291 0.81 NQO1 (0.82) NQO1TSHRTDP1ALDH1A1KDM4E
SCHEMBL18417193 0.81 NQO1 (0.82) NQO1TSHRTDP1ALDH1A1KDM4E
SCHEMBL5071281 0.80 RARB (0.48) FFAR1FFAR4CYP11B1CYP11B2RARA
SCHEMBL7247955 0.80 ERN1 (0.57) NQO1CHRNA7FFAR1FFAR4ALDH1A1
SCHEMBL19801798 0.80 CYP11B1 (0.71) CYP11B1CYP11B2
SCHEMBL7907955 0.80 GPR84 (0.42) NQO1CHRNA7FFAR1FFAR4ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0438575-A1 BENZOL DERIVATIVES AND LIQUID CRYSTALLINE MEDIUM. MERCK PATENT GMBH (DE) 1991-07-31 EP disclosed