Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.60 |
| ▸ | NPC1 | O15118 | 5/20 | 0.60 |
| ▸ | RAB9A | P51151 | 5/20 | 0.60 |
| ▸ | MAPT | P10636 | 4/20 | 0.60 |
| ▸ | MEN1 | O00255 | 4/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.60 |
| ▸ | GLA | P06280 | 1/20 | 0.60 |
| ▸ | TNNI3 | P19429 | 1/20 | 0.60 |
| ▸ | TNNT2 | P45379 | 1/20 | 0.60 |
| ▸ | TNNC1 | P63316 | 1/20 | 0.60 |
| ▸ | RUNX1 | Q01196 | 1/20 | 0.60 |
| ▸ | CBFB | Q13951 | 1/20 | 0.60 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | STAT1 | P42224 | 1/20 | 0.44 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.43 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12948580 | 0.81 | NPC1 (0.66) | KDM4ENPC1RAB9AMAPTMEN1 | |
| SCHEMBL5649400 | 0.80 | KDM4E (0.60) | KDM4ENPC1RAB9AMAPTMEN1 | |
| SCHEMBL20741514 | 0.79 | KDM4E (0.64) | KDM4ENPC1RAB9AMAPTMEN1 | |
| SCHEMBL20474248 | 0.79 | MAPT (0.59) | KDM4ENPC1RAB9AMAPTMEN1 | |
| SCHEMBL5646415 | 0.79 | KDM4E (0.59) | KDM4ENPC1RAB9AMAPTMEN1 | |
| SCHEMBL17967325 | 0.78 | KDM4E (0.62) | KDM4ENPC1RAB9AMAPTMEN1 | |
| Hydrochloric Acid SCHEMBL5647115 | 0.78 | KDM4E (0.57) | KDM4ENPC1RAB9AMAPTMEN1 | |
| SCHEMBL5645535 | 0.77 | KDM4E (0.56) | KDM4ENPC1RAB9AMAPTMEN1 | |
| SCHEMBL3584316 | 0.76 | MGLL (0.51) | NPC1RAB9AMAPTMEN1KMT2A | |
| SCHEMBL18075701 | 0.76 | KDM4E (1.00) | KDM4ENPC1RAB9AMAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220340893-A1 | BI-FUNCTIONAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES | NUEVOLUTION A/S (DK) | 2022-10-27 | — | — | US | disclosed |
| EP-2258676-B1 | STABLE VINAMIDINIUM SALT AND NITROGEN-CONTAINING HETEROCYCLIC RING SYNTHESIS USING THE SAME | TAKEDA PHARMACEUTICAL (JP) | 2016-02-17 | — | — | EP | disclosed |
| EP-2258676-B1 | STABLE VINAMIDINIUM SALT AND NITROGEN-CONTAINING HETEROCYCLIC RING SYNTHESIS USING THE SAME | TAKEDA PHARMACEUTICAL (JP) | 2016-02-17 | — | — | EP | disclosed |
| US-8373007-B2 | Stable vinamidinium salt and nitrogen-containing heterocyclic ring synthesis using the same | TAKEDA PHARMACEUTICAL COMPANY LTD. (JP) | 2013-02-12 | — | — | US | disclosed |
| US-8373007-B2 | Stable vinamidinium salt and nitrogen-containing heterocyclic ring synthesis using the same | TAKEDA PHARMACEUTICAL COMPANY LTD. (JP) | 2013-02-12 | — | — | US | disclosed |
| US-8373007-B2 | Stable vinamidinium salt and nitrogen-containing heterocyclic ring synthesis using the same | TAKEDA PHARMACEUTICAL COMPANY LTD. (JP) | 2013-02-12 | — | — | US | disclosed |
| US-20110015399-A1 | STABLE VINAMIDINIUM SALT AND NITROGEN-CONTAINING HETEROCYCLIC RING SYNTHESIS USING THE SAME | TAKEDA PHARMACEUTICAL COMPANY LTD. (JP) | 2011-01-20 | — | — | US | disclosed |
| US-20110015399-A1 | STABLE VINAMIDINIUM SALT AND NITROGEN-CONTAINING HETEROCYCLIC RING SYNTHESIS USING THE SAME | TAKEDA PHARMACEUTICAL COMPANY LTD. (JP) | 2011-01-20 | — | — | US | disclosed |
| EP-2258676-A1 | STABLE VINAMIDINIUM SALT AND NITROGEN-CONTAINING HETEROCYCLIC RING SYNTHESIS USING THE SAME | Takeda Pharmaceutical Company Limited (JP) | 2010-12-08 | — | — | EP | disclosed |
| EP-2258676-A1 | STABLE VINAMIDINIUM SALT AND NITROGEN-CONTAINING HETEROCYCLIC RING SYNTHESIS USING THE SAME | Takeda Pharmaceutical Company Limited (JP) | 2010-12-08 | — | — | EP | disclosed |
| US-7183415-B2 | Quinoline compound | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2007-02-27 | — | — | US | disclosed |
| US-20050209213-A1 | Quinoline compound | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2005-09-22 | — | — | US | disclosed |
| EP-1447402-A1 | QUINOLINE COMPOUND | Takeda Chemical Industries, Ltd. (JP) | 2004-08-18 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110015399-A1 | STABLE VINAMIDINIUM SALT AND NITROGEN-CONTAINING HETEROCYCLIC RING SYNTHESIS USING THE SAME | VRK2, H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16, NPM1 | KDM4E 1935/4885NPC1 3869/4885RAB9A 901/4885 |
| US-20050209213-A1 | Quinoline compound | MC1R, MC2R, TYR | KDM4E 2112/4885NPC1 1091/4885RAB9A 1128/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.