Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN8A | Q9UQD0 | 8/20 | 0.45 |
| ▸ | SCN1A | P35498 | 7/20 | 0.45 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.40 |
| ▸ | GRM5 | P41594 | 2/20 | 0.40 |
| ▸ | HTR2A | P28223 | 1/20 | 0.39 |
| ▸ | HTR2C | P28335 | 1/20 | 0.39 |
| ▸ | HTR2B | P41595 | 1/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.38 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL973549 | 0.94 | SCN8A (0.40) | SCN8ASCN1ASCN5AGRM5LMNA | |
| SCHEMBL4700276 | 0.93 | LMNA (0.43) | SCN8ASCN1AGRM5LMNAMAPK1 | |
| SCHEMBL973961 | 0.76 | GRIN2B (0.42) | SCN8ASCN1AGRM5RAB9AGRIN2B | |
| SCHEMBL3322466 | 0.75 | HTT (0.61) | SCN8ASCN1ALMNAMAPK1RAB9A | |
| SCHEMBL2852667 | 0.74 | SIGMAR1 (0.44) | SCN8ASCN1AGRM5HTR2AHTR2C | |
| SCHEMBL4700278 | 0.73 | GRM5 (0.45) | GRM5RAB9AGRIN2BALDH1A1 | |
| SCHEMBL973550 | 0.72 | GRM5 (0.40) | GRM5GRIN2BALDH1A1 | |
| SCHEMBL4701149 | 0.71 | GRIN2B (0.41) | SCN8ASCN1AGRM5HTR2AHTR2C | |
| SCHEMBL975924 | 0.70 | TRPM8 (0.39) | SCN8ASCN1AGRM5SIGMAR1LMNA | |
| SCHEMBL3144817 | 0.70 | GRM5 (0.52) | GRM5HTR2ALMNAMAPK1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7871999-B2 | Substituted thiazoles and their use for producing drugs | GRUENENTHAL GMBH (DE) | 2011-01-18 | — | — | US | claimed |
| EP-1968957-B1 | SUBSTITUTED THIAZOLES AND THEIR USE FOR PRODUCING DRUGS | GRUENENTHAL GMBH (DE) | 2010-01-20 | — | — | EP | claimed |
| EP-1968957-B1 | SUBSTITUTED THIAZOLES AND THEIR USE FOR PRODUCING DRUGS | GRUENENTHAL GMBH (DE) | 2010-01-20 | — | — | EP | disclosed |
| WO-2007079960-A9 | SUBSTITUTED THIAZOLES AND THEIR USE FOR PRODUCING DRUGS | GRUENENTHAL GMBH (DE) | 2008-10-23 | — | — | WO | disclosed |
| EP-1968957-A1 | SUBSTITUTED THIAZOLES AND THEIR USE FOR PRODUCING DRUGS | Grünenthal GmbH (DE) | 2008-09-17 | — | — | EP | disclosed |
| WO-2007079960-A1 | SUBSTITUTED THIAZOLES AND THEIR USE FOR PRODUCING DRUGS | Grünenthal GmbH (DE) | 2007-07-19 | — | — | WO | disclosed |